Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

Dong Eun Lee, Ah Young Kim, Hong Yeol Yoon, Ki Young Choi, Ick Chan Kwon, Seo Young Jeong, Jae Hyung Park, Kwang Meyung Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The amphiphilic hyaluronic acid-5β-cholanic acid (HA-CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical and magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs were preferentially accumulated in the tumor region, implying that the hydrophilic HA shells of nanoparticles allow prolonged circulation and excellent active targeting of the SPION encapsulated nanoparticles in tumor-bearing mice.

Original languageEnglish
Pages (from-to)10444-10447
Number of pages4
JournalJournal of Materials Chemistry
Volume22
Issue number21
DOIs
Publication statusPublished - 2012 Jun 7
Externally publishedYes

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Hyaluronic acid
Hyaluronic Acid
Magnetic resonance
Tumors
Nanoparticles
Imaging techniques
Bearings (structural)
Contrast Media
Coloring Agents
Dyes
Fluorescence
Infrared radiation
Acids
Water

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemistry(all)

Cite this

Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging. / Lee, Dong Eun; Kim, Ah Young; Yoon, Hong Yeol; Choi, Ki Young; Kwon, Ick Chan; Jeong, Seo Young; Park, Jae Hyung; Kim, Kwang Meyung.

In: Journal of Materials Chemistry, Vol. 22, No. 21, 07.06.2012, p. 10444-10447.

Research output: Contribution to journalArticle

Lee, DE, Kim, AY, Yoon, HY, Choi, KY, Kwon, IC, Jeong, SY, Park, JH & Kim, KM 2012, 'Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging', Journal of Materials Chemistry, vol. 22, no. 21, pp. 10444-10447. https://doi.org/10.1039/c2jm31406a
Lee, Dong Eun ; Kim, Ah Young ; Yoon, Hong Yeol ; Choi, Ki Young ; Kwon, Ick Chan ; Jeong, Seo Young ; Park, Jae Hyung ; Kim, Kwang Meyung. / Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging. In: Journal of Materials Chemistry. 2012 ; Vol. 22, No. 21. pp. 10444-10447.
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