AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

Shanshan Pei, Mohammad Minhajuddin, Biniam Adane, Nabilah Khan, Brett M. Stevens, Stephen C. Mack, Sisi Lai, Jeremy N. Rich, Anagha Inguva, Kevin M. Shannon, Hyunmin Kim, Aik Choon Tan, Jason R. Myers, John M. Ashton, Tobias Neff, Daniel A. Pollyea, Clayton A. Smith, Craig T. Jordan

Research output: Contribution to journalArticlepeer-review

131 Citations (Scopus)


Human acute myeloid leukemia stem cells (LSCs) depend on FIS1-mediated mitophagy for self-renewal and survival. AMPK is constitutively active in human LSCs, is upstream of FIS1, and acts to stimulate mitophagy. Disruption of AMPK signaling or FIS1 activity results in eradication of LSCs.

Original languageEnglish
Pages (from-to)86-100.e6
JournalCell Stem Cell
Issue number1
Publication statusPublished - 2018 Jul 5


  • AMPK
  • FIS1
  • GSK3
  • acute myeloid leukemia
  • differentiation
  • leukemia stem cells
  • mitochondrial dynamics
  • mitophagy

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology


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