Amplified photoacoustic performance and enhanced photothermal stability of reduced graphene oxide coated gold nanorods for sensitive photoacoustic imaging

Hyungwon Moon, Hyuncheol Kim, Dinesh Kumar, Haemin Kim, Changbeom Sim, Jin Ho Chang, Jung Mu Kim, Dong-Kwon Lim

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

We report a strongly amplified photoacoustic (PA) performance of the new functional hybrid material composed of reduced graphene oxide and gold nanorods. Due to the excellent NIR light absorption properties of the reduced graphene oxide coated gold nanorods (r-GO-AuNRs) and highly efficient heat transfer process through the reduced graphene oxide layer, r-GO-AuNRs exhibit excellent photothermal stability and significantly higher photoacoustic amplitudes than those of bare-AuNRs, nonreduced graphene oxide coated AuNRs (GO-AuNRs), or silica-coated AuNR, as demonstrated in both in vitro and in vivo systems. The linear response of PA amplitude from reduced state controlled GO on AuNR indicates the critical role of GO for a strong photothermal effect of r-GO-AuNRs. Theoretical studies with finite-element-method lab-based simulation reveal that a 4 times higher magnitude of the enhanced electromagnetic field around r-GO-AuNRs can be generated compared with bare AuNRs or GO-AuNRs. Furthermore, the r-GO-AuNRs are expected to be a promising deep-tissue imaging probe because of extraordinarily high PA amplitudes in the 4-11 MHz operating frequency of an ultrasound transducer. Therefore, the r-GO-AuNRs can be a useful imaging probe for highly sensitive photoacoustic images and NIR sensitive therapeutics based on a strong photothermal effect.

Original languageEnglish
Pages (from-to)2711-2719
Number of pages9
JournalACS Nano
Volume9
Issue number3
DOIs
Publication statusPublished - 2015 Mar 24

Fingerprint

Graphite
Photoacoustic effect
Nanorods
Gold
Oxides
Graphene
nanorods
graphene
gold
Imaging techniques
oxides
Functional materials
probes
Hybrid materials
electromagnetic absorption
Silicon Dioxide
Electromagnetic fields
Light absorption
Transducers
finite element method

Keywords

  • graphene-coated gold nanorods
  • photoacoustic imaging
  • photothermal effect

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Amplified photoacoustic performance and enhanced photothermal stability of reduced graphene oxide coated gold nanorods for sensitive photoacoustic imaging. / Moon, Hyungwon; Kim, Hyuncheol; Kumar, Dinesh; Kim, Haemin; Sim, Changbeom; Chang, Jin Ho; Kim, Jung Mu; Lim, Dong-Kwon.

In: ACS Nano, Vol. 9, No. 3, 24.03.2015, p. 2711-2719.

Research output: Contribution to journalArticle

Moon, Hyungwon ; Kim, Hyuncheol ; Kumar, Dinesh ; Kim, Haemin ; Sim, Changbeom ; Chang, Jin Ho ; Kim, Jung Mu ; Lim, Dong-Kwon. / Amplified photoacoustic performance and enhanced photothermal stability of reduced graphene oxide coated gold nanorods for sensitive photoacoustic imaging. In: ACS Nano. 2015 ; Vol. 9, No. 3. pp. 2711-2719.
@article{0b4e26c333d34b1c8e8ab5cd03548838,
title = "Amplified photoacoustic performance and enhanced photothermal stability of reduced graphene oxide coated gold nanorods for sensitive photoacoustic imaging",
abstract = "We report a strongly amplified photoacoustic (PA) performance of the new functional hybrid material composed of reduced graphene oxide and gold nanorods. Due to the excellent NIR light absorption properties of the reduced graphene oxide coated gold nanorods (r-GO-AuNRs) and highly efficient heat transfer process through the reduced graphene oxide layer, r-GO-AuNRs exhibit excellent photothermal stability and significantly higher photoacoustic amplitudes than those of bare-AuNRs, nonreduced graphene oxide coated AuNRs (GO-AuNRs), or silica-coated AuNR, as demonstrated in both in vitro and in vivo systems. The linear response of PA amplitude from reduced state controlled GO on AuNR indicates the critical role of GO for a strong photothermal effect of r-GO-AuNRs. Theoretical studies with finite-element-method lab-based simulation reveal that a 4 times higher magnitude of the enhanced electromagnetic field around r-GO-AuNRs can be generated compared with bare AuNRs or GO-AuNRs. Furthermore, the r-GO-AuNRs are expected to be a promising deep-tissue imaging probe because of extraordinarily high PA amplitudes in the 4-11 MHz operating frequency of an ultrasound transducer. Therefore, the r-GO-AuNRs can be a useful imaging probe for highly sensitive photoacoustic images and NIR sensitive therapeutics based on a strong photothermal effect.",
keywords = "graphene-coated gold nanorods, photoacoustic imaging, photothermal effect",
author = "Hyungwon Moon and Hyuncheol Kim and Dinesh Kumar and Haemin Kim and Changbeom Sim and Chang, {Jin Ho} and Kim, {Jung Mu} and Dong-Kwon Lim",
year = "2015",
month = "3",
day = "24",
doi = "10.1021/nn506516p",
language = "English",
volume = "9",
pages = "2711--2719",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "3",

}

TY - JOUR

T1 - Amplified photoacoustic performance and enhanced photothermal stability of reduced graphene oxide coated gold nanorods for sensitive photoacoustic imaging

AU - Moon, Hyungwon

AU - Kim, Hyuncheol

AU - Kumar, Dinesh

AU - Kim, Haemin

AU - Sim, Changbeom

AU - Chang, Jin Ho

AU - Kim, Jung Mu

AU - Lim, Dong-Kwon

PY - 2015/3/24

Y1 - 2015/3/24

N2 - We report a strongly amplified photoacoustic (PA) performance of the new functional hybrid material composed of reduced graphene oxide and gold nanorods. Due to the excellent NIR light absorption properties of the reduced graphene oxide coated gold nanorods (r-GO-AuNRs) and highly efficient heat transfer process through the reduced graphene oxide layer, r-GO-AuNRs exhibit excellent photothermal stability and significantly higher photoacoustic amplitudes than those of bare-AuNRs, nonreduced graphene oxide coated AuNRs (GO-AuNRs), or silica-coated AuNR, as demonstrated in both in vitro and in vivo systems. The linear response of PA amplitude from reduced state controlled GO on AuNR indicates the critical role of GO for a strong photothermal effect of r-GO-AuNRs. Theoretical studies with finite-element-method lab-based simulation reveal that a 4 times higher magnitude of the enhanced electromagnetic field around r-GO-AuNRs can be generated compared with bare AuNRs or GO-AuNRs. Furthermore, the r-GO-AuNRs are expected to be a promising deep-tissue imaging probe because of extraordinarily high PA amplitudes in the 4-11 MHz operating frequency of an ultrasound transducer. Therefore, the r-GO-AuNRs can be a useful imaging probe for highly sensitive photoacoustic images and NIR sensitive therapeutics based on a strong photothermal effect.

AB - We report a strongly amplified photoacoustic (PA) performance of the new functional hybrid material composed of reduced graphene oxide and gold nanorods. Due to the excellent NIR light absorption properties of the reduced graphene oxide coated gold nanorods (r-GO-AuNRs) and highly efficient heat transfer process through the reduced graphene oxide layer, r-GO-AuNRs exhibit excellent photothermal stability and significantly higher photoacoustic amplitudes than those of bare-AuNRs, nonreduced graphene oxide coated AuNRs (GO-AuNRs), or silica-coated AuNR, as demonstrated in both in vitro and in vivo systems. The linear response of PA amplitude from reduced state controlled GO on AuNR indicates the critical role of GO for a strong photothermal effect of r-GO-AuNRs. Theoretical studies with finite-element-method lab-based simulation reveal that a 4 times higher magnitude of the enhanced electromagnetic field around r-GO-AuNRs can be generated compared with bare AuNRs or GO-AuNRs. Furthermore, the r-GO-AuNRs are expected to be a promising deep-tissue imaging probe because of extraordinarily high PA amplitudes in the 4-11 MHz operating frequency of an ultrasound transducer. Therefore, the r-GO-AuNRs can be a useful imaging probe for highly sensitive photoacoustic images and NIR sensitive therapeutics based on a strong photothermal effect.

KW - graphene-coated gold nanorods

KW - photoacoustic imaging

KW - photothermal effect

UR - http://www.scopus.com/inward/record.url?scp=84925652433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925652433&partnerID=8YFLogxK

U2 - 10.1021/nn506516p

DO - 10.1021/nn506516p

M3 - Article

C2 - 25751167

AN - SCOPUS:84925652433

VL - 9

SP - 2711

EP - 2719

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 3

ER -