An amorphane sesquiterpene and a benzofuran glucoside from Eupatorium coelestinum

Dan Thi Thuy Hang, Tran Thi Hong Hanh, Chau Van Minh, Phan Van Kiem, Tran Huy Thai, Dongho Lee, Nguyen Tien Dat

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Abstract

A phytochemical investigation of the aerial parts of Eupatorium coelestinum led to the isolation of an amorphane sesquiterpene and a benzofuran glucoside. By means of spectroscopic methods, their structures were determined as 5α,8α-epoxy-4α,6β-dihydroxyamorphan-2-one (1) and 2R*,3S*-toxol-7-O-β-d-glucopyranoside (2). Compounds 1 significantly inhibited NF-κB activity in TNF-α-stimulated HeLa cells with the IC 50 of 12.4 μM.

Original languageEnglish
Pages (from-to)377-379
Number of pages3
JournalPhytochemistry Letters
Volume4
Issue number3
DOIs
Publication statusPublished - 2011 Sep 1

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Keywords

  • Amorphane sesquiterpene
  • Asteraceae
  • Benzofuran
  • Eupatorium coelestinum
  • NF-κB

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science
  • Biochemistry
  • Biotechnology

Cite this

Hang, D. T. T., Hanh, T. T. H., Van Minh, C., Van Kiem, P., Thai, T. H., Lee, D., & Dat, N. T. (2011). An amorphane sesquiterpene and a benzofuran glucoside from Eupatorium coelestinum. Phytochemistry Letters, 4(3), 377-379. https://doi.org/10.1016/j.phytol.2011.08.004