TY - JOUR
T1 - An Asian study on the prevalence of atypical respiratory pathogens in community-acquired pneumonia
AU - Ngeow, Yun Fong
AU - Suwanjutha, Subharee
AU - Chantarojanasriri, Teerachai
AU - Wang, Fu
AU - Saniel, Mediadora
AU - Alejandria, Marissa
AU - Hsueh, Po Ren
AU - Ping-Ing, Lee
AU - Park, Seung Chul
AU - Sohn, Jang Wook
AU - Aziah, Ahmad M.
AU - Liu, Youning
AU - Seto, Wing Hong
AU - Ngan, Cecilia C.L.
AU - Hadiarto, Mangunnegoro
AU - Hood, Alsagaff
AU - Cheong, Yuet Meng
N1 - Funding Information:
This study is supported by a grant from Pfizer Inc., New York. We are indebted to the following investigators who participated in this study: Mr Alex Lim Kuoh Chieh, Mr Cheong Soon Fatt, Professor Liam Chong Kin, Associate Professor Dr Patrick Chan Wai Kiong, Associate Professor Dr Khoo Ee Ming, Dr Lim Kim Hatt, Dr Vinothini, Madelene Liang, and Ms Lim Moi Heng (University Malaya Medical Center, Petaling Jaya); Assistant Professor Charn Kiatboonsri, Associate Professor Aroonwan Preuthipan, Dr Karl Kalavantanich, Dr Pichet Laouthaiwatthana, Ms. Metta Kham-in, Ms Sumanat Amsthan, Associate Professor Mongkol Kunakorn, Assistant Professor Kalayanee Attamasirikul, Ms. Arree Pornvoranunt, Ms Suwanee Chanampakul, Mr Chavachol Setthaudom, and Ms Kanchana Sriwanicharak, (Ramathibodi Hospital, Thailand); Associate Professor Nuanchan Prapphal, Associate Professor Sasithorn Likitnukul, Associate Professor Jitladda Deerojanavong, Dr Rujipat Samransamruakit, and Ms Chanthana Harnruthakorn (King Chulalongkorn Memorial Hospital, Thailand); Dr Sorasak Lochindarat, Dr Panida Srisan, Dr Thayanant Bunnag, Dr Pravit Jetanachai, Dr Wiboon Kanjanapattanakul, Ms Ura Charoenwan, and Ms Wanee Manyam (Queen Sirikit National Institute of Child Health, Thailand); Dr Pavin Durongkaveroj, Dr Somkid Oonsamathum, Dr Piraj Kateruttanakul, and Ms Penpun Sutham (Rajavithi Hospital, Thailand); Dr Yingsak Supanitayanon (Vajira Hospital, Thailand); Dr Pisit Janedittakarn, Dr Phanvadee Ratanasumawong, Ms Jarrevun Jankana, and Ms Sunanta Boonyuen (Police General Hospital, Thailand); Group Captain Suchada Voratarach, Wing Commander Thanason Thummakul, and Squadron Leader Taweesak Sirikunalai (Bhumibol Adulyadej Hospital, Thailand); Professor Zhang Yinhyuan and Dr Huang Haihui (Shanghai Huashan Hospital, Shanghai, China); Professor Huang Shaoguang, and Professor Li Min (Shanghai Ruijin Hospital, Shanghai, China); Professor Xiu Qingyu, Dr Fang Zheng, and Dr Huang Hai (Shanghai Changzheng Hospital, Shanghai, China); Professor Zhou Xin and Dr Li Qun (Shanghai First People's Hospital, Shanghai, China); Professor Wang Daiming and Professor Wang Xiaohong (Shanghai Children Hospital (Fudan University), Shanghai, China); Professor Lu Qian (Shanghai Children Hospital, Shanghai, China); Dr Raquel Ecarma, Ms Concepcion Ang, and Mr Marc Agnew Cajucom (Philippine General Hospital, Philippines); Mr Chung Ming Yi, Dr Chen Jong Min, Dr Yu Chong Jen, Ms. Tsai Yi Fen, Dr Fang Yin Hua, Dr Yang Chin Ying, and Ms. Lee Shu Han (National Taiwan University College of Medicine, Taipei, Taiwan); Dr Min Ja Kim, Dr Jin-Soo Lee, Ms. Hee-Sun Sim and Dr Hyun-il Choi (College of Medicine, Korea University, Seoul, South Korea); Dr Heung-Jeong Woo (Hangang Sacred Heart Hospital, Korea); Dr Yong Kyun Cho (Gil Medical Center, Gachon Medical School, Korea); Dr Young-Hwa Choi (Ajou University Hospital, Korea); Dr Fazilah Binti Ahmad, Dr Noor Arliza, Dr Ariza Adnan, Dr Norzila Mohamed Zainudin, Dr Rus Anida Bte Awang, Mrs Yew/Chew, Puan Shamsiah Md. Said, Puan Faridah Mohamed, and Dr Zubaidah bte Abdul Wahab (Kuala Lumpur General Hospital, Kuala Lumpur); Dr Chuah Siew Kee, and Dato Dr Shanta Kumari (Klang General Hospital, Selangor), Professor Wang Rui, Dr Zhao Tiemei, and Mr Liu Qingfeng (Chinese PLA General Hospital, Beijing, China); Professor Yao Wanzhen and Associate Professor Zhang Lisha (Third Hospital of Beijing University, Beijing, China); Professor He Zhengyi and Associate Professor Jiao Yunmin (Beijing Friendship Hospital, Beijing, China); Professor Duan Yunyou and Associate Professor Nie Zhoushan (Navy General Hospital of Chinese PLA, Beijing, China); Professor Kenneth Tsang, Dr Matthew Wong, Dr Simon Ip, Dr Vincent Cheng, Ms. Chan Mei Mei, and Dr Chan Kwok Hung (Queen Mary Hospital, the University of Hong Kong, Hong Kong); A/Professor Philip Eng Cher Tiew, Dr Steve Yang Tze Yi, Dr Low Su Ying, Dr Se-Thoe Su Yun, Dr Huang Shan Wei, and Ms Yap Chwee Bee (Singapore General Hospital, Singapore); Dr Priyanti ZS, Dr Elisna Syahruddin, and Dr Wiwien Heru Wiyono (Department of Respiratory Medicine, Faculty of Medicine, University of Indonesia, Persabahatan Hospital, Jakarta, Indonesia); Dr Soedarsono and Dr Manase Lulu (Dr Sutomo Hospital, Surabaya, Indonesia). We would also like to express our thanks to Ruth Koehnken from Focus Technology for providing the sera for the MIF test in the QA program, and Professor Ken Baker Waites from the University of Alabama for providing the Mycoplasma pneumoniae cultures for the QA program and for his invaluable advice in the start-up of the study.
PY - 2005/5
Y1 - 2005/5
N2 - Background: In many parts of Asia, the inaccessibility and high cost of diagnostic tests have hampered the study of community-acquired pneumonia (CAP) caused by atypical respiratory pathogens. Objective: This surveillance study examined the frequency of infection with Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila in 1756 patients presenting with signs and symptoms of CAP at 12 medical centres in Asia, using standardised laboratory techniques and interpretation criteria in all participating centres. Methods: Diagnosis of current infection was based on significant changes in antibody titer or persisting high antibody titers, together with the presence of bacterial DNA in respiratory secretions, in the case of M. pneumoniae and C. pneumoniae infections, or bacterial antigen in urine, in the case of L. pneumophila serogroup 1 infection. Results: Using these criteria, results from 1374 patients with paired sera showed that, overall, 23.5% of CAP cases were associated with infection with atypical respiratory pathogens, with M. pneumoniae, C. pneumoniae, and L. pneumophila being found in 12.2%, 4.7%, and 6.6% of cases, respectively. Persisting high antibody titers indicative of past exposure to M. pneumoniae, C. pneumoniae, and L. pneumophila were seen in 10.2%, 4.8%, and 18.9% of patients, respectively. Conclusion: These data reflect the overall high prevalence of these atypical pathogens among Asian patients with CAP.
AB - Background: In many parts of Asia, the inaccessibility and high cost of diagnostic tests have hampered the study of community-acquired pneumonia (CAP) caused by atypical respiratory pathogens. Objective: This surveillance study examined the frequency of infection with Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila in 1756 patients presenting with signs and symptoms of CAP at 12 medical centres in Asia, using standardised laboratory techniques and interpretation criteria in all participating centres. Methods: Diagnosis of current infection was based on significant changes in antibody titer or persisting high antibody titers, together with the presence of bacterial DNA in respiratory secretions, in the case of M. pneumoniae and C. pneumoniae infections, or bacterial antigen in urine, in the case of L. pneumophila serogroup 1 infection. Results: Using these criteria, results from 1374 patients with paired sera showed that, overall, 23.5% of CAP cases were associated with infection with atypical respiratory pathogens, with M. pneumoniae, C. pneumoniae, and L. pneumophila being found in 12.2%, 4.7%, and 6.6% of cases, respectively. Persisting high antibody titers indicative of past exposure to M. pneumoniae, C. pneumoniae, and L. pneumophila were seen in 10.2%, 4.8%, and 18.9% of patients, respectively. Conclusion: These data reflect the overall high prevalence of these atypical pathogens among Asian patients with CAP.
KW - Asia
KW - Atypical respiratory pathogens
KW - Community-acquired pneumonia
UR - http://www.scopus.com/inward/record.url?scp=20944448651&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2004.06.006
DO - 10.1016/j.ijid.2004.06.006
M3 - Article
C2 - 15840455
AN - SCOPUS:20944448651
SN - 1201-9712
VL - 9
SP - 144
EP - 153
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
IS - 3
ER -
