An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study

Ji Hye Huh, Dhananjay Yadav, Jae Seok Kim, Jung Woo Son, Eunhee Choi, Seong Hwan Kim, Chol Shin, Ki Chul Sung, Jang Young Kim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective Although metabolic abnormalities have been considered important risk factors of chronic kidney disease (CKD), the impact of metabolic syndrome (MS) and insulin resistance on renal function deterioration is poorly understood. We investigated the association between MS and incident CKD/rapid decline of estimated glomerular filtration rate (eGFR) in a 10-year population-based longitudinal study. Material and Methods Among 10,030 subjects, 6065 without history of CKD or cardiovascular disease at baseline were analyzed using data generated from the Ansan–Ansung cohort of the Korean Genome Epidemiology Study. Participants were categorized into two groups based on the presence of MS at baseline. Incident CKD was defined as eGFR < 60 ml/min per 1.73 m2, and rapid decline of eGFR was defined as > 3 ml/min per 1.73 m2/yr over 10 years. Results During the 10-year follow-up period, CKD developed in 893 subjects (14.7%). Compared to subjects without MS, the odds ratio (OR; 95% confidence interval, CI) of incident CKD in those with MS was 1.38 (1.16–1.64) after controlling for confounding factors. The risk of rapid decline of eGFR was also higher in subjects with MS than those without MS (OR: 1.20, 95% CI: 1.04–1.39). In addition, we found that higher levels of homeostatic model assessment of insulin resistance (HOMA-IR) were associated with incident CKD and rapid decline of eGFR independently of traditional CKD risk factors (OR: 1.24, 95% CI: 1.04–1.47). Conclusion Both MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population.

Original languageEnglish
Pages (from-to)54-61
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume67
DOIs
Publication statusPublished - 2017 Feb 1

Fingerprint

Chronic Renal Insufficiency
Cohort Studies
Prospective Studies
Glomerular Filtration Rate
Insulin Resistance
Confidence Intervals
Population
Longitudinal Studies
Epidemiology
Cardiovascular Diseases
Odds Ratio
Genome
Kidney

Keywords

  • Chronic kidney disease
  • Insulin resistance
  • Metabolic syndrome
  • Rapid decline of GFR

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study. / Huh, Ji Hye; Yadav, Dhananjay; Kim, Jae Seok; Son, Jung Woo; Choi, Eunhee; Kim, Seong Hwan; Shin, Chol; Sung, Ki Chul; Kim, Jang Young.

In: Metabolism: Clinical and Experimental, Vol. 67, 01.02.2017, p. 54-61.

Research output: Contribution to journalArticle

Huh, Ji Hye ; Yadav, Dhananjay ; Kim, Jae Seok ; Son, Jung Woo ; Choi, Eunhee ; Kim, Seong Hwan ; Shin, Chol ; Sung, Ki Chul ; Kim, Jang Young. / An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study. In: Metabolism: Clinical and Experimental. 2017 ; Vol. 67. pp. 54-61.
@article{cec63e1a62fc4f83b17eda2d061a08ba,
title = "An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study",
abstract = "Objective Although metabolic abnormalities have been considered important risk factors of chronic kidney disease (CKD), the impact of metabolic syndrome (MS) and insulin resistance on renal function deterioration is poorly understood. We investigated the association between MS and incident CKD/rapid decline of estimated glomerular filtration rate (eGFR) in a 10-year population-based longitudinal study. Material and Methods Among 10,030 subjects, 6065 without history of CKD or cardiovascular disease at baseline were analyzed using data generated from the Ansan–Ansung cohort of the Korean Genome Epidemiology Study. Participants were categorized into two groups based on the presence of MS at baseline. Incident CKD was defined as eGFR < 60 ml/min per 1.73 m2, and rapid decline of eGFR was defined as > 3 ml/min per 1.73 m2/yr over 10 years. Results During the 10-year follow-up period, CKD developed in 893 subjects (14.7{\%}). Compared to subjects without MS, the odds ratio (OR; 95{\%} confidence interval, CI) of incident CKD in those with MS was 1.38 (1.16–1.64) after controlling for confounding factors. The risk of rapid decline of eGFR was also higher in subjects with MS than those without MS (OR: 1.20, 95{\%} CI: 1.04–1.39). In addition, we found that higher levels of homeostatic model assessment of insulin resistance (HOMA-IR) were associated with incident CKD and rapid decline of eGFR independently of traditional CKD risk factors (OR: 1.24, 95{\%} CI: 1.04–1.47). Conclusion Both MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population.",
keywords = "Chronic kidney disease, Insulin resistance, Metabolic syndrome, Rapid decline of GFR",
author = "Huh, {Ji Hye} and Dhananjay Yadav and Kim, {Jae Seok} and Son, {Jung Woo} and Eunhee Choi and Kim, {Seong Hwan} and Chol Shin and Sung, {Ki Chul} and Kim, {Jang Young}",
year = "2017",
month = "2",
day = "1",
doi = "10.1016/j.metabol.2016.11.003",
language = "English",
volume = "67",
pages = "54--61",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study

AU - Huh, Ji Hye

AU - Yadav, Dhananjay

AU - Kim, Jae Seok

AU - Son, Jung Woo

AU - Choi, Eunhee

AU - Kim, Seong Hwan

AU - Shin, Chol

AU - Sung, Ki Chul

AU - Kim, Jang Young

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Objective Although metabolic abnormalities have been considered important risk factors of chronic kidney disease (CKD), the impact of metabolic syndrome (MS) and insulin resistance on renal function deterioration is poorly understood. We investigated the association between MS and incident CKD/rapid decline of estimated glomerular filtration rate (eGFR) in a 10-year population-based longitudinal study. Material and Methods Among 10,030 subjects, 6065 without history of CKD or cardiovascular disease at baseline were analyzed using data generated from the Ansan–Ansung cohort of the Korean Genome Epidemiology Study. Participants were categorized into two groups based on the presence of MS at baseline. Incident CKD was defined as eGFR < 60 ml/min per 1.73 m2, and rapid decline of eGFR was defined as > 3 ml/min per 1.73 m2/yr over 10 years. Results During the 10-year follow-up period, CKD developed in 893 subjects (14.7%). Compared to subjects without MS, the odds ratio (OR; 95% confidence interval, CI) of incident CKD in those with MS was 1.38 (1.16–1.64) after controlling for confounding factors. The risk of rapid decline of eGFR was also higher in subjects with MS than those without MS (OR: 1.20, 95% CI: 1.04–1.39). In addition, we found that higher levels of homeostatic model assessment of insulin resistance (HOMA-IR) were associated with incident CKD and rapid decline of eGFR independently of traditional CKD risk factors (OR: 1.24, 95% CI: 1.04–1.47). Conclusion Both MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population.

AB - Objective Although metabolic abnormalities have been considered important risk factors of chronic kidney disease (CKD), the impact of metabolic syndrome (MS) and insulin resistance on renal function deterioration is poorly understood. We investigated the association between MS and incident CKD/rapid decline of estimated glomerular filtration rate (eGFR) in a 10-year population-based longitudinal study. Material and Methods Among 10,030 subjects, 6065 without history of CKD or cardiovascular disease at baseline were analyzed using data generated from the Ansan–Ansung cohort of the Korean Genome Epidemiology Study. Participants were categorized into two groups based on the presence of MS at baseline. Incident CKD was defined as eGFR < 60 ml/min per 1.73 m2, and rapid decline of eGFR was defined as > 3 ml/min per 1.73 m2/yr over 10 years. Results During the 10-year follow-up period, CKD developed in 893 subjects (14.7%). Compared to subjects without MS, the odds ratio (OR; 95% confidence interval, CI) of incident CKD in those with MS was 1.38 (1.16–1.64) after controlling for confounding factors. The risk of rapid decline of eGFR was also higher in subjects with MS than those without MS (OR: 1.20, 95% CI: 1.04–1.39). In addition, we found that higher levels of homeostatic model assessment of insulin resistance (HOMA-IR) were associated with incident CKD and rapid decline of eGFR independently of traditional CKD risk factors (OR: 1.24, 95% CI: 1.04–1.47). Conclusion Both MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population.

KW - Chronic kidney disease

KW - Insulin resistance

KW - Metabolic syndrome

KW - Rapid decline of GFR

UR - http://www.scopus.com/inward/record.url?scp=84996931621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84996931621&partnerID=8YFLogxK

U2 - 10.1016/j.metabol.2016.11.003

DO - 10.1016/j.metabol.2016.11.003

M3 - Article

C2 - 28081778

AN - SCOPUS:84996931621

VL - 67

SP - 54

EP - 61

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

ER -