An automated method for identifying an independent component analysis-based language-related resting-state network in brain tumor subjects for surgical planning

Junfeng Lu, Han Zhang, N. U.Farrukh Hameed, Jie Zhang, Shiwen Yuan, Tianming Qiu, Dinggang Shen, Jinsong Wu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

As a noninvasive and "task-free" technique, resting-state functional magnetic resonance imaging (rs-fMRI) has been gradually applied to pre-surgical functional mapping. Independent component analysis (ICA)-based mapping has shown advantage, as no a priori information is required. We developed an automated method for identifying language network in brain tumor subjects using ICA on rs-fMRI. In addition to standard processing strategies, we applied a discriminability-index-based component identification algorithm to identify language networks in three different groups. The results from the training group were validated in an independent group of healthy human subjects. For the testing group, ICA and seed-based correlation were separately computed and the detected language networks were assessed by intra-operative stimulation mapping to verify reliability of application in the clinical setting. Individualized language network mapping could be automatically achieved for all subjects from the two healthy groups except one (19/20, success rate = 95.0%). In the testing group (brain tumor patients), the sensitivity of the language mapping result was 60.9%, which increased to 87.0% (superior to that of conventional seed-based correlation [47.8%]) after extending to a radius of 1 cm. We established an automatic and practical component identification method for rs-fMRI-based pre-surgical mapping and successfully applied it to brain tumor patients.

Original languageEnglish
Article number13769
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

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Brain Neoplasms
Language
Magnetic Resonance Imaging
Seeds
Healthy Volunteers

ASJC Scopus subject areas

  • General

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An automated method for identifying an independent component analysis-based language-related resting-state network in brain tumor subjects for surgical planning. / Lu, Junfeng; Zhang, Han; Hameed, N. U.Farrukh; Zhang, Jie; Yuan, Shiwen; Qiu, Tianming; Shen, Dinggang; Wu, Jinsong.

In: Scientific Reports, Vol. 7, No. 1, 13769, 01.12.2017.

Research output: Contribution to journalArticle

Lu, Junfeng ; Zhang, Han ; Hameed, N. U.Farrukh ; Zhang, Jie ; Yuan, Shiwen ; Qiu, Tianming ; Shen, Dinggang ; Wu, Jinsong. / An automated method for identifying an independent component analysis-based language-related resting-state network in brain tumor subjects for surgical planning. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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