An efficient preparation of 3-azabicyclo [3.3.0]. Oct-5-en-7-ones from propargyl alcohol- cobalt complexes via nicholas reaction with amidic nitrogen nucleophiles followed by pauson-khand cyclization

Nakcheol Jeong, Sung eun Yoo, Sang Jo Lee, Sang Hee Lee, Young Keun Chung

Research output: Contribution to journalArticle

54 Citations (Scopus)


3-Azabicyclo [3.3.0]-oct-5-en-7-ones were efficiently prepared from cobalt-propagyl alcohol complexes and various allyl amides via Nicholas reaction in the presence of BF3Et2O followed by Pauson-Khand cyclization promoted with trimethylamine N-oxide or SiO2.

Original languageEnglish
Pages (from-to)2137-2140
Number of pages4
JournalTetrahedron Letters
Issue number19
Publication statusPublished - 1991 May 6
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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