An electrostatic micromechanical biosensor for electrical detection of label-free DNA

Ji Min Choi, Sung Up Hwang, Chang Hoon Kim, Hyun Ho Yang, Cheulhee Jung, Hyun Gyu Park, Jun Bo Yoon, Yang Kyu Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An electrostatic micromechanical biosensor is demonstrated for the label-free electrical detection of DNA, based on electrostatic actuation of a double-clamped micromechanical cantilever by driving gate electrodes to establish a current path through drain and source electrodes. Intrinsic charges in DNA alter surface charges on the gate by pre-charging concept and change the pull-in voltage (V PI), the voltage required to bring the suspended cantilever into contact with the drain electrode by induced electrostatic force. Its operation principle is verified by a numerical simulation and a capacitive model. The proposed biosensor represents a breakthrough for practical exploitation of electro-mechanical based sensors.

Original languageEnglish
Article number163701
JournalApplied Physics Letters
Volume100
Issue number16
DOIs
Publication statusPublished - 2012 Apr 16
Externally publishedYes

Fingerprint

bioinstrumentation
deoxyribonucleic acid
electrostatics
electrodes
electric potential
exploitation
actuation
charging
sensors
simulation

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Choi, J. M., Hwang, S. U., Kim, C. H., Yang, H. H., Jung, C., Gyu Park, H., ... Choi, Y. K. (2012). An electrostatic micromechanical biosensor for electrical detection of label-free DNA. Applied Physics Letters, 100(16), [163701]. https://doi.org/10.1063/1.3703764

An electrostatic micromechanical biosensor for electrical detection of label-free DNA. / Choi, Ji Min; Hwang, Sung Up; Kim, Chang Hoon; Yang, Hyun Ho; Jung, Cheulhee; Gyu Park, Hyun; Yoon, Jun Bo; Choi, Yang Kyu.

In: Applied Physics Letters, Vol. 100, No. 16, 163701, 16.04.2012.

Research output: Contribution to journalArticle

Choi, JM, Hwang, SU, Kim, CH, Yang, HH, Jung, C, Gyu Park, H, Yoon, JB & Choi, YK 2012, 'An electrostatic micromechanical biosensor for electrical detection of label-free DNA', Applied Physics Letters, vol. 100, no. 16, 163701. https://doi.org/10.1063/1.3703764
Choi, Ji Min ; Hwang, Sung Up ; Kim, Chang Hoon ; Yang, Hyun Ho ; Jung, Cheulhee ; Gyu Park, Hyun ; Yoon, Jun Bo ; Choi, Yang Kyu. / An electrostatic micromechanical biosensor for electrical detection of label-free DNA. In: Applied Physics Letters. 2012 ; Vol. 100, No. 16.
@article{de010d6bc3bb4ccd88b76d4ac952cc5d,
title = "An electrostatic micromechanical biosensor for electrical detection of label-free DNA",
abstract = "An electrostatic micromechanical biosensor is demonstrated for the label-free electrical detection of DNA, based on electrostatic actuation of a double-clamped micromechanical cantilever by driving gate electrodes to establish a current path through drain and source electrodes. Intrinsic charges in DNA alter surface charges on the gate by pre-charging concept and change the pull-in voltage (V PI), the voltage required to bring the suspended cantilever into contact with the drain electrode by induced electrostatic force. Its operation principle is verified by a numerical simulation and a capacitive model. The proposed biosensor represents a breakthrough for practical exploitation of electro-mechanical based sensors.",
author = "Choi, {Ji Min} and Hwang, {Sung Up} and Kim, {Chang Hoon} and Yang, {Hyun Ho} and Cheulhee Jung and {Gyu Park}, Hyun and Yoon, {Jun Bo} and Choi, {Yang Kyu}",
year = "2012",
month = "4",
day = "16",
doi = "10.1063/1.3703764",
language = "English",
volume = "100",
journal = "Applied Physics Letters",
issn = "0003-6951",
publisher = "American Institute of Physics Publising LLC",
number = "16",

}

TY - JOUR

T1 - An electrostatic micromechanical biosensor for electrical detection of label-free DNA

AU - Choi, Ji Min

AU - Hwang, Sung Up

AU - Kim, Chang Hoon

AU - Yang, Hyun Ho

AU - Jung, Cheulhee

AU - Gyu Park, Hyun

AU - Yoon, Jun Bo

AU - Choi, Yang Kyu

PY - 2012/4/16

Y1 - 2012/4/16

N2 - An electrostatic micromechanical biosensor is demonstrated for the label-free electrical detection of DNA, based on electrostatic actuation of a double-clamped micromechanical cantilever by driving gate electrodes to establish a current path through drain and source electrodes. Intrinsic charges in DNA alter surface charges on the gate by pre-charging concept and change the pull-in voltage (V PI), the voltage required to bring the suspended cantilever into contact with the drain electrode by induced electrostatic force. Its operation principle is verified by a numerical simulation and a capacitive model. The proposed biosensor represents a breakthrough for practical exploitation of electro-mechanical based sensors.

AB - An electrostatic micromechanical biosensor is demonstrated for the label-free electrical detection of DNA, based on electrostatic actuation of a double-clamped micromechanical cantilever by driving gate electrodes to establish a current path through drain and source electrodes. Intrinsic charges in DNA alter surface charges on the gate by pre-charging concept and change the pull-in voltage (V PI), the voltage required to bring the suspended cantilever into contact with the drain electrode by induced electrostatic force. Its operation principle is verified by a numerical simulation and a capacitive model. The proposed biosensor represents a breakthrough for practical exploitation of electro-mechanical based sensors.

UR - http://www.scopus.com/inward/record.url?scp=84859957291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859957291&partnerID=8YFLogxK

U2 - 10.1063/1.3703764

DO - 10.1063/1.3703764

M3 - Article

AN - SCOPUS:84859957291

VL - 100

JO - Applied Physics Letters

JF - Applied Physics Letters

SN - 0003-6951

IS - 16

M1 - 163701

ER -