Utilizing knowledge of the problem of interest and lessons learned from solving similar problems would help to find the final optimal solution of better quality. A hyper-heuristic algorithm is to gain an advantage of such process. In this paper, we present an evolutionary algorithm based hyper-heuristic framework for solving the set packing problem (SPP). The SPP is a typical NP-hard problem. The hyper-heuristic is comprising of high level and low level. The higher level is mainly engaged in generating or constructing a heuristic. An evolutionary algorithm with guided mutation (EA/G) is employed at the high level. Whereas a set of problem-independent and problem-specific heuristics, called low level heuristics, are employed at the low level of hyper-heuristic. EA/G is recently added to the class of the evolutionary algorithms that try to utilize the complementary characteristics of genetic algorithms (GAs) and estimation of distribution algorithms (EDAs) to generate new offspring. In EA/G, the guided mutation operator generates an offspring by sampling the probability vector. The proposed approach is compared with the state-of-the-art approaches reported in the literature. The computational results show the effectiveness of the proposed approach.