An example-based multi-atlas approach to automatic labeling of white matter tracts

Sang Wook Yoo, Pamela Guevara, Yong Jeong, Kwangsun Yoo, Joseph S. Shin, Jean Francois Mangin, Jun Kyung Seong

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We present an example-based multi-atlas approach for classifying white matter (WM) tracts into anatomic bundles. Our approach exploits expert-provided example data to automatically classify the WM tracts of a subject. Multiple atlases are constructed to model the example data from multiple subjects in order to reflect the individual variability of bundle shapes and trajectories over subjects. For each example subject, an atlas is maintained to allow the example data of a subject to be added or deleted flexibly. A voting scheme is proposed to facilitate the multi-atlas exploitation of example data. For conceptual simplicity, we adopt the same metrics in both example data construction and WM tract labeling. Due to the huge number of WM tracts in a subject, it is time-consuming to label each WM tract individually. Thus, the WM tracts are grouped according to their shape similarity, and WM tracts within each group are labeled simultaneously. To further enhance the computational efficiency, we implemented our approach on the graphics processing unit (GPU). Through nested cross-validation we demonstrated that our approach yielded high classification performance. The average sensitivities for bundles in the left and right hemispheres were 89.5% and 91.0%, respectively, and their average false discovery rates were 14.9% and 14.2%, respectively.

Original languageEnglish
Article numbere0133337
JournalPLoS One
Volume10
Issue number7
DOIs
Publication statusPublished - 2015 Jul 30

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Atlases
Computational efficiency
Labeling
Labels
Trajectories
trajectories
Politics
Graphics processing unit
White Matter

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Yoo, S. W., Guevara, P., Jeong, Y., Yoo, K., Shin, J. S., Mangin, J. F., & Seong, J. K. (2015). An example-based multi-atlas approach to automatic labeling of white matter tracts. PLoS One, 10(7), [e0133337]. https://doi.org/10.1371/journal.pone.0133337

An example-based multi-atlas approach to automatic labeling of white matter tracts. / Yoo, Sang Wook; Guevara, Pamela; Jeong, Yong; Yoo, Kwangsun; Shin, Joseph S.; Mangin, Jean Francois; Seong, Jun Kyung.

In: PLoS One, Vol. 10, No. 7, e0133337, 30.07.2015.

Research output: Contribution to journalArticle

Yoo, SW, Guevara, P, Jeong, Y, Yoo, K, Shin, JS, Mangin, JF & Seong, JK 2015, 'An example-based multi-atlas approach to automatic labeling of white matter tracts', PLoS One, vol. 10, no. 7, e0133337. https://doi.org/10.1371/journal.pone.0133337
Yoo SW, Guevara P, Jeong Y, Yoo K, Shin JS, Mangin JF et al. An example-based multi-atlas approach to automatic labeling of white matter tracts. PLoS One. 2015 Jul 30;10(7). e0133337. https://doi.org/10.1371/journal.pone.0133337
Yoo, Sang Wook ; Guevara, Pamela ; Jeong, Yong ; Yoo, Kwangsun ; Shin, Joseph S. ; Mangin, Jean Francois ; Seong, Jun Kyung. / An example-based multi-atlas approach to automatic labeling of white matter tracts. In: PLoS One. 2015 ; Vol. 10, No. 7.
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