An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report

Man Gao, Hui Pang, Young Mi Kim, Xianglan Lu, Xianfu Wang, Jiyun Lee, Mingwei Wang, Fanzheng Meng, Shibo Li

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Translocation (9;11)(p21.3;q23.3) is one of the most common lysine methyltransferase 2A (KMT2A)-rearrangements in de novo and therapy-related acute myeloid leukemia (AML). Numerous in vitro and in vivo studies have demonstrated that the KMT2A/MLLT3 super elongation complex subunit (MLLT3) fusion gene on the derivative chromosome 11 serves a crucial role in leukemogenesis. Trisomy 9 as a secondary chromosome change in patients with t(9;11) is relatively rare. The present study reported a unique case of AML with a chromosome 9 trisomy secondary to t(9;11)(p21.3;q23.3) through the cytogenetic analysis of leukemic blood and bone marrow. Further characterization with fluorescence in situ hybridization and array comparative genomic hybridization analysis revealed that this extra chromosome 9 was either a copy of normal chromosome 9 or a derivative chromosome 9. Conversely with the previously reported favorable outcome of AML patients with t(9;11)(p21.3;q23.3), in the present study, the cells with only translocation persisted, whereas the cells with an extra chromosome 9 disappeared following initial chemotherapy. With this unique case, the present study hypothesized that the extra chromosome 9 could serve a crucial role in AML disease progression and contribute to cellular sensitivity to chemotherapy.

    Original languageEnglish
    Pages (from-to)6725-6731
    Number of pages7
    JournalOncology Letters
    Volume18
    Issue number6
    DOIs
    Publication statusPublished - 2019

    Keywords

    • Acute myeloid leukemia
    • Disease progression
    • T(9;11)(p21.3;q23.3)
    • Trisomy 9

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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