An herbal medicine mixture (HM-10) induces longitudinal bone growth and growth hormone release in rats

Sung Sun Park, Sung Hoon Oh, Song Hwan Bae, Jung Min Kim, Un Jae Chang, Jung Min Park, Jin Man Kim, Hyung Joo Suh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To investigate the growth promoting effects of an herbal medicine formulation (HM-10), Sprague Dawley (SD) male rats (3 weeks old) were divided into 3 groups (8 rats/group). The control group was given a daily oral administration of saline, and the treatment groups, HM-1 and HM-2, were given daily administrations of HM-10 (500 and 1,000 mg/kg BW, respectively). The cumulative tibial bone growth of the HM-1 and HM-2 groups (22.5 and 20.8 mm, respectively), and their cumulative femur bone growth (19.4 and 18.2 mm, respectively), were significantly different compared to the control group (7.5 mm of tibial growth and 7.7 mm of femur growth) (p<0.05). Lastly, the growth hormone levels of the HM-1 and HM-2 groups (1.70 and 1.79 ng/mL, respectively), as well as their insulin like growth factor 1 (IGF-1) levels (165.1 and 171.7 ng/ mL, respectively) showed significant differences compared to the control (0.93 ng/mL of growth hormone and 125.6 ng/mL of IGF-1) (p<0.05).

Original languageEnglish
Pages (from-to)1046-1050
Number of pages5
JournalFood Science and Biotechnology
Volume16
Issue number6
Publication statusPublished - 2007 Dec 1

Fingerprint

Herbal Medicine
Bone Development
herbal medicines
somatomedins
femur
somatotropin
Growth Hormone
bones
Somatomedins
Femur
rats
Growth
oral administration
Control Groups
Oral Administration
Sprague Dawley Rats
Therapeutics

Keywords

  • Growth hormone
  • Herbal medicine
  • Insulin like growth factor 1
  • Longitudinal bone growth

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

An herbal medicine mixture (HM-10) induces longitudinal bone growth and growth hormone release in rats. / Park, Sung Sun; Oh, Sung Hoon; Bae, Song Hwan; Kim, Jung Min; Chang, Un Jae; Park, Jung Min; Kim, Jin Man; Suh, Hyung Joo.

In: Food Science and Biotechnology, Vol. 16, No. 6, 01.12.2007, p. 1046-1050.

Research output: Contribution to journalArticle

Park, Sung Sun ; Oh, Sung Hoon ; Bae, Song Hwan ; Kim, Jung Min ; Chang, Un Jae ; Park, Jung Min ; Kim, Jin Man ; Suh, Hyung Joo. / An herbal medicine mixture (HM-10) induces longitudinal bone growth and growth hormone release in rats. In: Food Science and Biotechnology. 2007 ; Vol. 16, No. 6. pp. 1046-1050.
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