Abstract
To investigate the growth promoting effects of an herbal medicine formulation (HM-10), Sprague Dawley (SD) male rats (3 weeks old) were divided into 3 groups (8 rats/group). The control group was given a daily oral administration of saline, and the treatment groups, HM-1 and HM-2, were given daily administrations of HM-10 (500 and 1,000 mg/kg BW, respectively). The cumulative tibial bone growth of the HM-1 and HM-2 groups (22.5 and 20.8 mm, respectively), and their cumulative femur bone growth (19.4 and 18.2 mm, respectively), were significantly different compared to the control group (7.5 mm of tibial growth and 7.7 mm of femur growth) (p<0.05). Lastly, the growth hormone levels of the HM-1 and HM-2 groups (1.70 and 1.79 ng/mL, respectively), as well as their insulin like growth factor 1 (IGF-1) levels (165.1 and 171.7 ng/ mL, respectively) showed significant differences compared to the control (0.93 ng/mL of growth hormone and 125.6 ng/mL of IGF-1) (p<0.05).
| Original language | English |
|---|---|
| Pages (from-to) | 1046-1050 |
| Number of pages | 5 |
| Journal | Food Science and Biotechnology |
| Volume | 16 |
| Issue number | 6 |
| Publication status | Published - 2007 |
Keywords
- Growth hormone
- Herbal medicine
- Insulin like growth factor 1
- Longitudinal bone growth
ASJC Scopus subject areas
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology