An iminocoumarin-Cu(ii) ensemble-based chemodosimeter toward thiols

Hyo Sung Jung, Ji Hye Han, Yoichi Habata, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

An 'ensemble'-based fluoregenic chemodosimeter 1-Cu(ii) for detection of thiols is reported. Complex 1-Cu(ii) sensitively senses thiols followed by hydrolysis to give a marked fluorescence enhancement over other amino acids at pH 7.4 under aqueous media. Confocal microscopic imaging of complex 1-Cu(ii) is also herewith demonstrated for cellular thiol detection in HepG2 cells.

Original languageEnglish
Pages (from-to)5142-5144
Number of pages3
JournalChemical Communications
Volume47
Issue number18
DOIs
Publication statusPublished - 2011 May 14

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Sulfhydryl Compounds
Amino acids
Hydrolysis
Fluorescence
Imaging techniques
Hep G2 Cells
Amino Acids

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

An iminocoumarin-Cu(ii) ensemble-based chemodosimeter toward thiols. / Jung, Hyo Sung; Han, Ji Hye; Habata, Yoichi; Kang, Chulhun; Kim, Jong Seung.

In: Chemical Communications, Vol. 47, No. 18, 14.05.2011, p. 5142-5144.

Research output: Contribution to journalArticle

Jung, Hyo Sung ; Han, Ji Hye ; Habata, Yoichi ; Kang, Chulhun ; Kim, Jong Seung. / An iminocoumarin-Cu(ii) ensemble-based chemodosimeter toward thiols. In: Chemical Communications. 2011 ; Vol. 47, No. 18. pp. 5142-5144.
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