Abstract
Background: Uric acid is a novel cardiovascular disease (CVD) factor, but its use as an independent risk factor for CVD remains controversial. Here, we examined the correlation between Framingham risk score (FRS) and serum uric acid concentrations in asymptomatic Korean adults. Methods: This cross-sectional study was performed on 8035 Korean adults. Besides FRS, we measured body mass index, fasting blood glucose, homeostasis model assessment of insulin resistance, creatinine, γ-glutamyltransferase, the lipid profile, uric acid, high-sensitive C-reactive protein, and the white blood cell count. All subjects were placed into one of three risk groups according to their FRS. Results: All CVD related factors were significantly different in the three FRS groups. The increments of uric acid in-creased significantly FRS from the 10-year risk 0%-9% group to the >10% group after adjusting for other CVD-related factors using ordinal logistic regression analysis. Analyses of the three age groups showed similar effects. Conclusions: An increased uric acid concentration is associated with an increase in coronary heart disease risk calculated from the FRS, and doctors need to pay attention to this CVD risk in apparently healthy adults with hyperuricemia.
| Original language | English |
|---|---|
| Pages (from-to) | 909-914 |
| Number of pages | 6 |
| Journal | Clinical Chemistry and Laboratory Medicine |
| Volume | 49 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2011 May 1 |
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Keywords
- cardiovascular disease
- coronary heart disease
- Framingham risk score
- risk factors
- uric acid
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical
Cite this
An increase in serum uric acid concentrations is associated with an increase in the Framingham risk score in Korean adults. / Nam, Ga Eun; Lee, Kyung Shik; Park, Yong Gyu; Cho, Kyung-Hwan; Lee, Seung Hwan; Ko, Byung Joon; Kim, Do-Hoon.
In: Clinical Chemistry and Laboratory Medicine, Vol. 49, No. 5, 01.05.2011, p. 909-914.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An increase in serum uric acid concentrations is associated with an increase in the Framingham risk score in Korean adults
AU - Nam, Ga Eun
AU - Lee, Kyung Shik
AU - Park, Yong Gyu
AU - Cho, Kyung-Hwan
AU - Lee, Seung Hwan
AU - Ko, Byung Joon
AU - Kim, Do-Hoon
PY - 2011/5/1
Y1 - 2011/5/1
N2 - Background: Uric acid is a novel cardiovascular disease (CVD) factor, but its use as an independent risk factor for CVD remains controversial. Here, we examined the correlation between Framingham risk score (FRS) and serum uric acid concentrations in asymptomatic Korean adults. Methods: This cross-sectional study was performed on 8035 Korean adults. Besides FRS, we measured body mass index, fasting blood glucose, homeostasis model assessment of insulin resistance, creatinine, γ-glutamyltransferase, the lipid profile, uric acid, high-sensitive C-reactive protein, and the white blood cell count. All subjects were placed into one of three risk groups according to their FRS. Results: All CVD related factors were significantly different in the three FRS groups. The increments of uric acid in-creased significantly FRS from the 10-year risk 0%-9% group to the >10% group after adjusting for other CVD-related factors using ordinal logistic regression analysis. Analyses of the three age groups showed similar effects. Conclusions: An increased uric acid concentration is associated with an increase in coronary heart disease risk calculated from the FRS, and doctors need to pay attention to this CVD risk in apparently healthy adults with hyperuricemia.
AB - Background: Uric acid is a novel cardiovascular disease (CVD) factor, but its use as an independent risk factor for CVD remains controversial. Here, we examined the correlation between Framingham risk score (FRS) and serum uric acid concentrations in asymptomatic Korean adults. Methods: This cross-sectional study was performed on 8035 Korean adults. Besides FRS, we measured body mass index, fasting blood glucose, homeostasis model assessment of insulin resistance, creatinine, γ-glutamyltransferase, the lipid profile, uric acid, high-sensitive C-reactive protein, and the white blood cell count. All subjects were placed into one of three risk groups according to their FRS. Results: All CVD related factors were significantly different in the three FRS groups. The increments of uric acid in-creased significantly FRS from the 10-year risk 0%-9% group to the >10% group after adjusting for other CVD-related factors using ordinal logistic regression analysis. Analyses of the three age groups showed similar effects. Conclusions: An increased uric acid concentration is associated with an increase in coronary heart disease risk calculated from the FRS, and doctors need to pay attention to this CVD risk in apparently healthy adults with hyperuricemia.
KW - cardiovascular disease
KW - coronary heart disease
KW - Framingham risk score
KW - risk factors
KW - uric acid
UR - http://www.scopus.com/inward/record.url?scp=79954463886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954463886&partnerID=8YFLogxK
U2 - 10.1515/CCLM.2011.124
DO - 10.1515/CCLM.2011.124
M3 - Article
C2 - 21288174
AN - SCOPUS:79954463886
VL - 49
SP - 909
EP - 914
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
SN - 1434-6621
IS - 5
ER -