An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH)

W. Jung, J. Han, J. Kai, J. Y. Lim, Dong Geun Sul, C. H. Ahn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A new sample-to-answer polymer lab-on-a-chip, which can perform immunoassay with minimum user intervention through on-chip reservoirs for reagents and single microchannel assay, has been designed, developed and successfully characterized as a point-of-care testing (POCT) cartridge for the detection of thyroid stimulating hormone (TSH). Users only need to drop a sample to the POCT cartridge to obtain test results within 30 minutes. The analyzed results of TSH showed a linear range up to 55 μIU/mL with the limit of detection (LOD) of 1.9 μIU/mL at the signal to noise ratio (SNR) of 3. The reagents stored in the on-chip reservoirs maintained their volume more than 97 % of initial volume for 100 days of storage time while the detection antibody retained its activity above 97 %.

Original languageEnglish
Title of host publicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pages1053-1056
Number of pages4
DOIs
Publication statusPublished - 2013 Apr 2
EventIEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013 - Taipei, Taiwan, Province of China
Duration: 2013 Jan 202013 Jan 24

Other

OtherIEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
CountryTaiwan, Province of China
CityTaipei
Period13/1/2013/1/24

Fingerprint

Lab-on-a-chip
hormones
Thyrotropin
cartridges
Polymers
chips
reagents
polymers
Testing
Microchannels
Antibodies
Assays
Signal to noise ratio
immunoassay
microchannels
antibodies
signal to noise ratios
Thyroid Hormones

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Jung, W., Han, J., Kai, J., Lim, J. Y., Sul, D. G., & Ahn, C. H. (2013). An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH). In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 1053-1056). [6474430] https://doi.org/10.1109/MEMSYS.2013.6474430

An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH). / Jung, W.; Han, J.; Kai, J.; Lim, J. Y.; Sul, Dong Geun; Ahn, C. H.

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2013. p. 1053-1056 6474430.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jung, W, Han, J, Kai, J, Lim, JY, Sul, DG & Ahn, CH 2013, An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH). in Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)., 6474430, pp. 1053-1056, IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013, Taipei, Taiwan, Province of China, 13/1/20. https://doi.org/10.1109/MEMSYS.2013.6474430
Jung W, Han J, Kai J, Lim JY, Sul DG, Ahn CH. An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH). In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2013. p. 1053-1056. 6474430 https://doi.org/10.1109/MEMSYS.2013.6474430
Jung, W. ; Han, J. ; Kai, J. ; Lim, J. Y. ; Sul, Dong Geun ; Ahn, C. H. / An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH). Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2013. pp. 1053-1056
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