An InSb-based magnetoresistive biosensor using Fe3O4 nanoparticles

Sung Jong Kim, Seung Woo Lee, Jin Dong Song, Young Wan Kwon, Kyoung Jin Lee, Hyun Cheol Koo

Research output: Contribution to journalArticle

Abstract

A magnetoresistive biosensor was demonstrated using an InSb-based semiconductor channel. The Fe3O4 nanoparticle was linked with a target antigen via a capture antibody in the reagent, and a detection antibody immobilized on an InSb channel was shown to selectively bind to the antigen-capture antibody-nanoparticle complex. The detected magnetic nanoparticles produced a stray magnetic field that induced a change in the resistance of the channel due to the Lorentz force. The antigen concentration was proportional to the number of nanoparticles attached to the sensor surface, and hence could be determined by measuring the magnetoresistance level of the sensing channel. This antigen-antibody reaction sensor was shown to detect an extremely small amount of liver cancer antigen, at a concentration as low as 1pg/ml. The systematic tests we carried out also confirmed the good selectivity and reusability of this biosensor.

Original languageEnglish
JournalSensors and Actuators, B: Chemical
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

antigens
Antigens
bioinstrumentation
Biosensors
antibodies
Antibodies
Nanoparticles
nanoparticles
Antigen-antibody reactions
Immobilized Antibodies
Lorentz force
Sensors
Reusability
Magnetoresistance
Liver
sensors
liver
reagents
Semiconductor materials
Magnetic fields

Keywords

  • Antigen-antibody reaction
  • Biosensor
  • InSb
  • Magnetoresistive sensor
  • Nanoparticle

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

An InSb-based magnetoresistive biosensor using Fe3O4 nanoparticles. / Kim, Sung Jong; Lee, Seung Woo; Song, Jin Dong; Kwon, Young Wan; Lee, Kyoung Jin; Koo, Hyun Cheol.

In: Sensors and Actuators, B: Chemical, 2017.

Research output: Contribution to journalArticle

Kim, Sung Jong ; Lee, Seung Woo ; Song, Jin Dong ; Kwon, Young Wan ; Lee, Kyoung Jin ; Koo, Hyun Cheol. / An InSb-based magnetoresistive biosensor using Fe3O4 nanoparticles. In: Sensors and Actuators, B: Chemical. 2017.
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