An InSb-based magnetoresistive biosensor using Fe3O4 nanoparticles

Sung Jong Kim, Seung Woo Lee, Jin Dong Song, Young Wan Kwon, Kyung Jin Lee, Hyun Cheol Koo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A magnetoresistive biosensor was demonstrated using an InSb-based semiconductor channel. The Fe3O4 nanoparticle was linked with a target antigen via a capture antibody in the reagent, and a detection antibody immobilized on an InSb channel was shown to selectively bind to the antigen-capture antibody-nanoparticle complex. The detected magnetic nanoparticles produced a stray magnetic field that induced a change in the resistance of the channel due to the Lorentz force. The antigen concentration was proportional to the number of nanoparticles attached to the sensor surface, and hence could be determined by measuring the magnetoresistance level of the sensing channel. This antigen-antibody reaction sensor was shown to detect an extremely small amount of liver cancer antigen, at a concentration as low as 1 pg/ml. The systematic tests we carried out also confirmed the good selectivity and reusability of this biosensor.

Original languageEnglish
Pages (from-to)2894-2899
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume255
DOIs
Publication statusPublished - 2018 Feb

Keywords

  • Antigen-antibody reaction
  • Biosensor
  • InSb
  • Magnetoresistive sensor
  • Nanoparticle

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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