An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats

Ji Yeong Kim, Woo Joo Jeon, Dong Hwee Kim, Im Joo Rhyu, Young Hwan Kim, Inchan Youn, Jong Woong Park

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with platelet-rich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.

Original languageEnglish
Pages (from-to)1351-1357
Number of pages7
JournalNeural Regeneration Research
Volume9
Issue number14
DOIs
Publication statusPublished - 2014 Jul 15

Keywords

  • Axon diameter
  • Histology
  • Inside-out vein autograft
  • Myelin sheath thickness
  • Myelinated axons
  • Nerve regeneration
  • Neural regeneration
  • Peripheral nerve injury
  • Platelet-rich plasma
  • Sciatic nerve
  • Sciatic nerve index

ASJC Scopus subject areas

  • Developmental Neuroscience

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