An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females

Boung Chul Lee, Jae W. Yang, So H. Lee, Seung Hyun Kim, Sook Haeng Joe, In K. Jung, Ihn Geun Choi, Byung-Joo Ham

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic system, to elucidate their relationship with personality. A total of 245 normal female Koreans (age 23.05 ± 3.07 years, mean ± SD) volunteered to take part in this study. They filled out a Korean version of the Temperament and Character Inventory (TCI) and were genotyped for the NET and MAOA-VNTR; the NET T-182C and MAOA-uVNTR polymorphisms were checked. We found significant main effect of NET genotype on novelty seeking (NS) score (F = 5.43, p = 0.021) and significant interaction between the NET and MAOA-uVNTR polymorphisms on NS score (F = 11.06, p = 0.001). However, there were no relationship between MAOA-uVNTR polymorphisms and NS score, and no association with other temperamental dimensions and these two polymorphisms. Our findings suggest that this functional polymorphism in the noradrenergic gene is associated with novelty seeking in Korean females.

Original languageEnglish
Pages (from-to)238-242
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume32
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1

Fingerprint

Norepinephrine Plasma Membrane Transport Proteins
Monoamine Oxidase
Personality
Minisatellite Repeats
Temperament
Adrenergic Agents
Genotype
Equipment and Supplies
Genes

Keywords

  • Genes
  • Monoamine oxidase-A
  • Norepinephrine transporter
  • Personality
  • Polymorphism

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females. / Lee, Boung Chul; Yang, Jae W.; Lee, So H.; Kim, Seung Hyun; Joe, Sook Haeng; Jung, In K.; Choi, Ihn Geun; Ham, Byung-Joo.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 32, No. 1, 01.01.2008, p. 238-242.

Research output: Contribution to journalArticle

@article{1ed3788bad69499dacf9a5be64eb81bd,
title = "An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females",
abstract = "The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic system, to elucidate their relationship with personality. A total of 245 normal female Koreans (age 23.05 ± 3.07 years, mean ± SD) volunteered to take part in this study. They filled out a Korean version of the Temperament and Character Inventory (TCI) and were genotyped for the NET and MAOA-VNTR; the NET T-182C and MAOA-uVNTR polymorphisms were checked. We found significant main effect of NET genotype on novelty seeking (NS) score (F = 5.43, p = 0.021) and significant interaction between the NET and MAOA-uVNTR polymorphisms on NS score (F = 11.06, p = 0.001). However, there were no relationship between MAOA-uVNTR polymorphisms and NS score, and no association with other temperamental dimensions and these two polymorphisms. Our findings suggest that this functional polymorphism in the noradrenergic gene is associated with novelty seeking in Korean females.",
keywords = "Genes, Monoamine oxidase-A, Norepinephrine transporter, Personality, Polymorphism",
author = "Lee, {Boung Chul} and Yang, {Jae W.} and Lee, {So H.} and Kim, {Seung Hyun} and Joe, {Sook Haeng} and Jung, {In K.} and Choi, {Ihn Geun} and Byung-Joo Ham",
year = "2008",
month = "1",
day = "1",
doi = "10.1016/j.pnpbp.2007.08.014",
language = "English",
volume = "32",
pages = "238--242",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females

AU - Lee, Boung Chul

AU - Yang, Jae W.

AU - Lee, So H.

AU - Kim, Seung Hyun

AU - Joe, Sook Haeng

AU - Jung, In K.

AU - Choi, Ihn Geun

AU - Ham, Byung-Joo

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic system, to elucidate their relationship with personality. A total of 245 normal female Koreans (age 23.05 ± 3.07 years, mean ± SD) volunteered to take part in this study. They filled out a Korean version of the Temperament and Character Inventory (TCI) and were genotyped for the NET and MAOA-VNTR; the NET T-182C and MAOA-uVNTR polymorphisms were checked. We found significant main effect of NET genotype on novelty seeking (NS) score (F = 5.43, p = 0.021) and significant interaction between the NET and MAOA-uVNTR polymorphisms on NS score (F = 11.06, p = 0.001). However, there were no relationship between MAOA-uVNTR polymorphisms and NS score, and no association with other temperamental dimensions and these two polymorphisms. Our findings suggest that this functional polymorphism in the noradrenergic gene is associated with novelty seeking in Korean females.

AB - The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic system, to elucidate their relationship with personality. A total of 245 normal female Koreans (age 23.05 ± 3.07 years, mean ± SD) volunteered to take part in this study. They filled out a Korean version of the Temperament and Character Inventory (TCI) and were genotyped for the NET and MAOA-VNTR; the NET T-182C and MAOA-uVNTR polymorphisms were checked. We found significant main effect of NET genotype on novelty seeking (NS) score (F = 5.43, p = 0.021) and significant interaction between the NET and MAOA-uVNTR polymorphisms on NS score (F = 11.06, p = 0.001). However, there were no relationship between MAOA-uVNTR polymorphisms and NS score, and no association with other temperamental dimensions and these two polymorphisms. Our findings suggest that this functional polymorphism in the noradrenergic gene is associated with novelty seeking in Korean females.

KW - Genes

KW - Monoamine oxidase-A

KW - Norepinephrine transporter

KW - Personality

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=38349060172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38349060172&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2007.08.014

DO - 10.1016/j.pnpbp.2007.08.014

M3 - Article

VL - 32

SP - 238

EP - 242

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 1

ER -