An oldie but goodie: Lithium in the treatment of bipolar disorder through neuroprotective and neurotrophic mechanisms

Eunsoo Won, Yong Ku Kim

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more years, and recent studies with more reliable designs and updated guidelines have recommended lithium to be the treatment of choice for acute manic, mixed and depressive episodes of BD, along with long-term prophylaxis. Lithium’s specific mechanism of action in mood regulation is progressively being clarified, such as the direct inhibition on glycogen synthase kinase 3β, and its various effects on neurotrophic factors, neurotransmitters, oxidative metabolism, apoptosis, second messenger systems, and biological systems are also being revealed. Furthermore, lithium has been proposed to exert its treatment effects through mechanisms associated with neuronal plasticity. In this review, we have overviewed the clinical aspects of lithium use for BD, and have focused on the neuroprotective and neurotrophic effects of lithium.

Original languageEnglish
Article number2679
JournalInternational Journal of Molecular Sciences
Volume18
Issue number12
DOIs
Publication statusPublished - 2017 Dec 11

Fingerprint

Bipolar Disorder
Lithium
lithium
disorders
prophylaxis
moods
glycogens
neurotransmitters
Glycogen Synthase Kinase 3
Neuronal Plasticity
Nerve Growth Factors
apoptosis
Second Messenger Systems
Neuroprotective Agents
metabolism
Cell death
Biological systems
Metabolism
plastic properties
Plasticity

Keywords

  • Bipolar disorder
  • Lithium
  • Therapeutic mechanism

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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