An olig2 reporter gene marks oligodendrocyte precursors in the postembryonic spinal cord of zebrafish

Hae Chul Park, Jimann Shin, Randolph K. Roberts, Bruce Appel

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Continuous production of new neurons and glia in adult mammals occurs within specialized proliferation zones of the forebrain. Neural cell proliferation and neurogenesis is more widespread in adult amphibians, reptiles, and fish but the identity of neural stem cell populations in these organisms has not been fully described. We investigated expression of a reporter gene driven by olig2 regulatory DNA at postembryonic stages in zebrafish. We show that olig2 expression marks a discrete population of spinal cord radial glia in larvae and adults that divide continuously. olig2+ radial glia have hallmarks of stem cells and their divisions appear to be asymmetric, producing new oligodendrocytes but not neurons or astrocytes.

Original languageEnglish
Pages (from-to)3402-3407
Number of pages6
JournalDevelopmental Dynamics
Volume236
Issue number12
DOIs
Publication statusPublished - 2007 Dec 1

Fingerprint

Oligodendroglia
Zebrafish
Reporter Genes
Neuroglia
Spinal Cord
Neurons
Reptiles
Neural Stem Cells
Neurogenesis
Amphibians
Prosencephalon
Astrocytes
Cell Division
Population
Larva
Mammals
Fishes
Stem Cells
Cell Proliferation
DNA

Keywords

  • Adult neural stem cell
  • Oligodendrocyte progenitor
  • Radial glia
  • Spinal cord
  • Zebrafish transgenic

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Cite this

An olig2 reporter gene marks oligodendrocyte precursors in the postembryonic spinal cord of zebrafish. / Park, Hae Chul; Shin, Jimann; Roberts, Randolph K.; Appel, Bruce.

In: Developmental Dynamics, Vol. 236, No. 12, 01.12.2007, p. 3402-3407.

Research output: Contribution to journalArticle

Park, Hae Chul ; Shin, Jimann ; Roberts, Randolph K. ; Appel, Bruce. / An olig2 reporter gene marks oligodendrocyte precursors in the postembryonic spinal cord of zebrafish. In: Developmental Dynamics. 2007 ; Vol. 236, No. 12. pp. 3402-3407.
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