An outbreak of Heinz body positive hemolytic anemia in chronic hemodialysis patients.

H. J. Pyo, Young-Joo Kwon, K. S. Wee, S. Y. Kwon, C. H. Lee, S. Kim, J. S. Lee, S. H. Cho, C. W. Cha

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

During the four month period, from December 1988 to March 1989, there was an outbreak of Heinz body positive hemolytic anemia in 34 patients undergoing hemodialysis in a 500-bed hospital, Seoul, Korea. The episodes of hemolysis were not reduced by changing the charcoal column and reverse osmosis system, or by adding ascorbic acid to the dialysate. The concentrations of nitrate, copper, aluminum and zinc in the treated water were all within the standards for hemodialysis. The chloramine concentration of the treated water was over 0.6 mg/L, markedly exceeding the allowable level of 0.1 mg/L. This high level of chloramine was proved to be due to the contamination of the water source by raw sewage. After we changed the source of water supply to another, no more episodes of hemolytic anemia occurred. It is concluded that chloramine is one of the major contaminants causing dialysis-induced hemolytic anemia and regular determinations are necessary, especially during winter and dry seasons.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalKorean Journal of Internal Medicine
Volume8
Issue number2
Publication statusPublished - 1993 Jul 1

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Heinz Bodies
Hemolytic Anemia
Disease Outbreaks
Renal Dialysis
Water
Osmosis
Water Supply
Charcoal
Dialysis Solutions
Korea
Sewage
Hemolysis
Ascorbic Acid
Copper
Dialysis
chloramine

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Pyo, H. J., Kwon, Y-J., Wee, K. S., Kwon, S. Y., Lee, C. H., Kim, S., ... Cha, C. W. (1993). An outbreak of Heinz body positive hemolytic anemia in chronic hemodialysis patients. Korean Journal of Internal Medicine, 8(2), 93-98.

An outbreak of Heinz body positive hemolytic anemia in chronic hemodialysis patients. / Pyo, H. J.; Kwon, Young-Joo; Wee, K. S.; Kwon, S. Y.; Lee, C. H.; Kim, S.; Lee, J. S.; Cho, S. H.; Cha, C. W.

In: Korean Journal of Internal Medicine, Vol. 8, No. 2, 01.07.1993, p. 93-98.

Research output: Contribution to journalArticle

Pyo, HJ, Kwon, Y-J, Wee, KS, Kwon, SY, Lee, CH, Kim, S, Lee, JS, Cho, SH & Cha, CW 1993, 'An outbreak of Heinz body positive hemolytic anemia in chronic hemodialysis patients.', Korean Journal of Internal Medicine, vol. 8, no. 2, pp. 93-98.
Pyo, H. J. ; Kwon, Young-Joo ; Wee, K. S. ; Kwon, S. Y. ; Lee, C. H. ; Kim, S. ; Lee, J. S. ; Cho, S. H. ; Cha, C. W. / An outbreak of Heinz body positive hemolytic anemia in chronic hemodialysis patients. In: Korean Journal of Internal Medicine. 1993 ; Vol. 8, No. 2. pp. 93-98.
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