An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy

Rongzhan Fu; Kyungeun Jeon; Cheulhee Jung; Hyun Gyu Park

doi:10.1039/c1cc13122b

An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy

Rongzhan Fu, Kyungeun Jeon, Cheulhee Jung, Hyun Gyu Park

Research output: Contribution to journal › Article

31 Citations (Scopus)

Abstract

By rationally employing enzymes for signal amplification, an ultrasensitive aptasensor was developed and successfully tested in a system designed to detect lysozyme with a detection limit of 0.1 fM. This detection limit is nearly three orders of magnitude lower than those of any previously reported DNAzyme-based aptasensors.

Original language	English
Pages (from-to)	9876-9878
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	35
DOIs	https://doi.org/10.1039/c1cc13122b
Publication status	Published - 2011 Sep 21
Externally published	Yes

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ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Cite this

Fu, R., Jeon, K., Jung, C., & Park, H. G. (2011). An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy. Chemical Communications, 47(35), 9876-9878. https://doi.org/10.1039/c1cc13122b

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Access to Document

10.1039/c1cc13122b