An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy

Rongzhan Fu; Kyungeun Jeon; Cheulhee Jung; Hyun Gyu Park

doi:10.1039/c1cc13122b

An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy

Rongzhan Fu, Kyungeun Jeon, Cheulhee Jung, Hyun Gyu Park

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

By rationally employing enzymes for signal amplification, an ultrasensitive aptasensor was developed and successfully tested in a system designed to detect lysozyme with a detection limit of 0.1 fM. This detection limit is nearly three orders of magnitude lower than those of any previously reported DNAzyme-based aptasensors.

Original language	English
Pages (from-to)	9876-9878
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	35
DOIs	https://doi.org/10.1039/c1cc13122b
Publication status	Published - 2011 Sep 21
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc13122b

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title = "An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy",

abstract = "By rationally employing enzymes for signal amplification, an ultrasensitive aptasensor was developed and successfully tested in a system designed to detect lysozyme with a detection limit of 0.1 fM. This detection limit is nearly three orders of magnitude lower than those of any previously reported DNAzyme-based aptasensors.",

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AU - Fu, Rongzhan

AU - Jeon, Kyungeun

AU - Jung, Cheulhee

AU - Park, Hyun Gyu

PY - 2011/9/21

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AB - By rationally employing enzymes for signal amplification, an ultrasensitive aptasensor was developed and successfully tested in a system designed to detect lysozyme with a detection limit of 0.1 fM. This detection limit is nearly three orders of magnitude lower than those of any previously reported DNAzyme-based aptasensors.

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DO - 10.1039/c1cc13122b

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An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy

Abstract

ASJC Scopus subject areas

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