An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy

Rongzhan Fu, Kyungeun Jeon, Cheulhee Jung, Hyun Gyu Park

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

By rationally employing enzymes for signal amplification, an ultrasensitive aptasensor was developed and successfully tested in a system designed to detect lysozyme with a detection limit of 0.1 fM. This detection limit is nearly three orders of magnitude lower than those of any previously reported DNAzyme-based aptasensors.

Original languageEnglish
Pages (from-to)9876-9878
Number of pages3
JournalChemical Communications
Volume47
Issue number35
DOIs
Publication statusPublished - 2011 Sep 21
Externally publishedYes

Fingerprint

Catalytic DNA
Muramidase
Peroxidase
Amplification
Limit of Detection
Enzymes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy. / Fu, Rongzhan; Jeon, Kyungeun; Jung, Cheulhee; Park, Hyun Gyu.

In: Chemical Communications, Vol. 47, No. 35, 21.09.2011, p. 9876-9878.

Research output: Contribution to journalArticle

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