Analgesic effect and inhibition of prostaglandin E 2 activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula

Soon Yong Kwon, Hwa Sung Lee, Soon Hyuck Lee, Gun Il Im, Si Na Kim, Hee Seok Kim, Sung Wan Hwang, Sung Yeoun Hwang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

New herbal formula (NHF) is the ethanol extract mixture of Puerariae radix, Artemisia capillaries and Perilla frutescens. We have investigated the effects on anti-inflammation by NHF and attempted acetic acid induced writhing to verify the analgesic effect. Macrophages and chondrocytes were obtained from mouse and rabbit. Inflammation was induced by interleukin-1, tumor necrosis factor-α, interferon-γ, and lipopolysaccharide. NHF showed strong inhibitory efficacy against cytokine-induced proteoglycan degradation, PGE 2 production, NO production, and MMP-9 expression in rabbit articular chondrocyte. In the writhing test, NHF exhibited a dose-dependent inhibition of writhing. Futhermore, NHF increased the activity of SOD. NHF have anti-inflammatory and analgesic activities, and could be a good herbal medicine candidate for curing of osteoarthritis.

Original languageEnglish
Pages (from-to)136-142
Number of pages7
JournalKorean Journal of Pharmacognosy
Volume37
Issue number3
Publication statusPublished - 2006 Sep

Keywords

  • Analgesic
  • Anti-inflammation
  • MMPs
  • Osteoarthritis
  • PGE

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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