Analgesic effect and inhibition of prostaglandin E 2 activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula

Soon Yong Kwon; Hwa Sung Lee; Soon Hyuck Lee; Gun Il Im; Si Na Kim; Hee Seok Kim; Sung Wan Hwang; Sung Yeoun Hwang

Analgesic effect and inhibition of prostaglandin E ₂ activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula

Soon Yong Kwon, Hwa Sung Lee, Soon Hyuck Lee, Gun Il Im, Si Na Kim, Hee Seok Kim, Sung Wan Hwang, Sung Yeoun Hwang

Research output: Contribution to journal › Article › peer-review

Abstract

New herbal formula (NHF) is the ethanol extract mixture of Puerariae radix, Artemisia capillaries and Perilla frutescens. We have investigated the effects on anti-inflammation by NHF and attempted acetic acid induced writhing to verify the analgesic effect. Macrophages and chondrocytes were obtained from mouse and rabbit. Inflammation was induced by interleukin-1, tumor necrosis factor-α, interferon-γ, and lipopolysaccharide. NHF showed strong inhibitory efficacy against cytokine-induced proteoglycan degradation, PGE ₂ production, NO production, and MMP-9 expression in rabbit articular chondrocyte. In the writhing test, NHF exhibited a dose-dependent inhibition of writhing. Futhermore, NHF increased the activity of SOD. NHF have anti-inflammatory and analgesic activities, and could be a good herbal medicine candidate for curing of osteoarthritis.

Original language	English
Pages (from-to)	136-142
Number of pages	7
Journal	Korean Journal of Pharmacognosy
Volume	37
Issue number	3
Publication status	Published - 2006 Sept

Keywords

Analgesic
Anti-inflammation
MMPs
Osteoarthritis
PGE

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science
Drug Discovery

Cite this

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title = "Analgesic effect and inhibition of prostaglandin E 2 activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula",

abstract = "New herbal formula (NHF) is the ethanol extract mixture of Puerariae radix, Artemisia capillaries and Perilla frutescens. We have investigated the effects on anti-inflammation by NHF and attempted acetic acid induced writhing to verify the analgesic effect. Macrophages and chondrocytes were obtained from mouse and rabbit. Inflammation was induced by interleukin-1, tumor necrosis factor-α, interferon-γ, and lipopolysaccharide. NHF showed strong inhibitory efficacy against cytokine-induced proteoglycan degradation, PGE 2 production, NO production, and MMP-9 expression in rabbit articular chondrocyte. In the writhing test, NHF exhibited a dose-dependent inhibition of writhing. Futhermore, NHF increased the activity of SOD. NHF have anti-inflammatory and analgesic activities, and could be a good herbal medicine candidate for curing of osteoarthritis.",

keywords = "Analgesic, Anti-inflammation, MMPs, Osteoarthritis, PGE",

author = "Kwon, {Soon Yong} and Lee, {Hwa Sung} and Lee, {Soon Hyuck} and Im, {Gun Il} and Kim, {Si Na} and Kim, {Hee Seok} and Hwang, {Sung Wan} and Hwang, {Sung Yeoun}",

year = "2006",

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language = "English",

volume = "37",

pages = "136--142",

journal = "Korean Journal of Pharmacognosy",

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T1 - Analgesic effect and inhibition of prostaglandin E 2 activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula

AU - Kwon, Soon Yong

AU - Lee, Hwa Sung

AU - Lee, Soon Hyuck

AU - Im, Gun Il

AU - Kim, Si Na

AU - Kim, Hee Seok

AU - Hwang, Sung Wan

AU - Hwang, Sung Yeoun

PY - 2006/9

Y1 - 2006/9

N2 - New herbal formula (NHF) is the ethanol extract mixture of Puerariae radix, Artemisia capillaries and Perilla frutescens. We have investigated the effects on anti-inflammation by NHF and attempted acetic acid induced writhing to verify the analgesic effect. Macrophages and chondrocytes were obtained from mouse and rabbit. Inflammation was induced by interleukin-1, tumor necrosis factor-α, interferon-γ, and lipopolysaccharide. NHF showed strong inhibitory efficacy against cytokine-induced proteoglycan degradation, PGE 2 production, NO production, and MMP-9 expression in rabbit articular chondrocyte. In the writhing test, NHF exhibited a dose-dependent inhibition of writhing. Futhermore, NHF increased the activity of SOD. NHF have anti-inflammatory and analgesic activities, and could be a good herbal medicine candidate for curing of osteoarthritis.

AB - New herbal formula (NHF) is the ethanol extract mixture of Puerariae radix, Artemisia capillaries and Perilla frutescens. We have investigated the effects on anti-inflammation by NHF and attempted acetic acid induced writhing to verify the analgesic effect. Macrophages and chondrocytes were obtained from mouse and rabbit. Inflammation was induced by interleukin-1, tumor necrosis factor-α, interferon-γ, and lipopolysaccharide. NHF showed strong inhibitory efficacy against cytokine-induced proteoglycan degradation, PGE 2 production, NO production, and MMP-9 expression in rabbit articular chondrocyte. In the writhing test, NHF exhibited a dose-dependent inhibition of writhing. Futhermore, NHF increased the activity of SOD. NHF have anti-inflammatory and analgesic activities, and could be a good herbal medicine candidate for curing of osteoarthritis.

KW - Analgesic

KW - Anti-inflammation

KW - MMPs

KW - Osteoarthritis

KW - PGE

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VL - 37

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JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 3

ER -

Analgesic effect and inhibition of prostaglandin E ₂ activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula

Abstract

Keywords

ASJC Scopus subject areas

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