Analgesic effect and inhibition of prostaglandin E 2 activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula

Soon Yong Kwon, Hwa Sung Lee, Soon-Hyuck Lee, Gun Il Im, Si Na Kim, Hee Seok Kim, Sung Wan Hwang, Sung Yeoun Hwang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

New herbal formula (NHF) is the ethanol extract mixture of Puerariae radix, Artemisia capillaries and Perilla frutescens. We have investigated the effects on anti-inflammation by NHF and attempted acetic acid induced writhing to verify the analgesic effect. Macrophages and chondrocytes were obtained from mouse and rabbit. Inflammation was induced by interleukin-1, tumor necrosis factor-α, interferon-γ, and lipopolysaccharide. NHF showed strong inhibitory efficacy against cytokine-induced proteoglycan degradation, PGE 2 production, NO production, and MMP-9 expression in rabbit articular chondrocyte. In the writhing test, NHF exhibited a dose-dependent inhibition of writhing. Futhermore, NHF increased the activity of SOD. NHF have anti-inflammatory and analgesic activities, and could be a good herbal medicine candidate for curing of osteoarthritis.

Original languageEnglish
Pages (from-to)136-142
Number of pages7
JournalKorean Journal of Pharmacognosy
Volume37
Issue number3
Publication statusPublished - 2006 Sep 1

Fingerprint

Chondrocytes
Prostaglandins E
Analgesics
Perilla frutescens
Ethanol
Cytokines
Rabbits
Inflammation
Artemisia
Herbal Medicine
Non-Steroidal Anti-Inflammatory Agents
Proteoglycans
Matrix Metalloproteinases
Interleukin-1
Acetic Acid
Osteoarthritis
Interferons
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Joints

Keywords

  • Analgesic
  • Anti-inflammation
  • MMPs
  • Osteoarthritis
  • PGE

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Analgesic effect and inhibition of prostaglandin E 2 activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula. / Kwon, Soon Yong; Lee, Hwa Sung; Lee, Soon-Hyuck; Im, Gun Il; Kim, Si Na; Kim, Hee Seok; Hwang, Sung Wan; Hwang, Sung Yeoun.

In: Korean Journal of Pharmacognosy, Vol. 37, No. 3, 01.09.2006, p. 136-142.

Research output: Contribution to journalArticle

Kwon, Soon Yong ; Lee, Hwa Sung ; Lee, Soon-Hyuck ; Im, Gun Il ; Kim, Si Na ; Kim, Hee Seok ; Hwang, Sung Wan ; Hwang, Sung Yeoun. / Analgesic effect and inhibition of prostaglandin E 2 activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula. In: Korean Journal of Pharmacognosy. 2006 ; Vol. 37, No. 3. pp. 136-142.
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