Analgesic effect of intra-articular injection of temperature-responsive hydrogel containing bupivacaine on osteoarthritic pain in rats

Taemin Kim, Dong Rim Seol, Suk Chan Hahm, Cheolwoong Ko, Eun Hye Kim, Keyoungjin Chun, Junesun Kim, Tae Hong Lim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The present study examined the analgesic effects of slow-releasing bupivacaine from hydrogel on chronic arthritic pain in rats. Osteoarthritis (OA) was induced by monosodium iodoacetate (MIA) injection into the right knee joint. Hydrogel (HG: 20, 30, and 50 L) and temperature-sensitive hydrogel containing bupivacaine (T-gel: 20, 30, and 50 L) were injected intra-articularly 14 days after MIA injection. Behavioral tests were conducted. The rats showed a significant decrease in weight load and paw withdrawal threshold (PWT). Intra-articular 0.5% bupivacaine (10 and 20 L) significantly reversed MIA-induced decreased PWT, with no effect on weight load. In normal rats, hydrogel did not produce significant changes in PWT but at 30 and 50 L slightly decreased weight bearing; T-gel did not cause any changes in both the weight load and PWT. In OA rats, T-gel at 20 L had a significant analgesic effect for 2 days, even though T-gel at 50 L further reduced the weight load, demonstrating that intra-articular T-gel (20 L) has long-lasting analgesic effects in OA rats. Thus, T-gel designed to deliver analgesics into the joint cavity could be an effective therapeutic tool in the clinical setting.

Original languageEnglish
Article number812949
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

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Intra-Articular Injections
Hydrogel
Bupivacaine
Analgesics
Rats
Gels
Iodoacetates
Pain
Temperature
Osteoarthritis
Weights and Measures
Joints
Bearings (structural)
Injections
Weight-Bearing
Knee Joint
Chronic Pain
Arthritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Analgesic effect of intra-articular injection of temperature-responsive hydrogel containing bupivacaine on osteoarthritic pain in rats. / Kim, Taemin; Seol, Dong Rim; Hahm, Suk Chan; Ko, Cheolwoong; Kim, Eun Hye; Chun, Keyoungjin; Kim, Junesun; Lim, Tae Hong.

In: BioMed Research International, Vol. 2015, 812949, 2015.

Research output: Contribution to journalArticle

Kim, Taemin ; Seol, Dong Rim ; Hahm, Suk Chan ; Ko, Cheolwoong ; Kim, Eun Hye ; Chun, Keyoungjin ; Kim, Junesun ; Lim, Tae Hong. / Analgesic effect of intra-articular injection of temperature-responsive hydrogel containing bupivacaine on osteoarthritic pain in rats. In: BioMed Research International. 2015 ; Vol. 2015.
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