Analgesic effect of intra-articular injection of temperature-responsive hydrogel containing bupivacaine on osteoarthritic pain in rats

Taemin Kim, Dong Rim Seol, Suk Chan Hahm, Cheolwoong Ko, Eun Hye Kim, Keyoungjin Chun, Junesun Kim, Tae Hong Lim

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The present study examined the analgesic effects of slow-releasing bupivacaine from hydrogel on chronic arthritic pain in rats. Osteoarthritis (OA) was induced by monosodium iodoacetate (MIA) injection into the right knee joint. Hydrogel (HG: 20, 30, and 50 L) and temperature-sensitive hydrogel containing bupivacaine (T-gel: 20, 30, and 50 L) were injected intra-articularly 14 days after MIA injection. Behavioral tests were conducted. The rats showed a significant decrease in weight load and paw withdrawal threshold (PWT). Intra-articular 0.5% bupivacaine (10 and 20 L) significantly reversed MIA-induced decreased PWT, with no effect on weight load. In normal rats, hydrogel did not produce significant changes in PWT but at 30 and 50 L slightly decreased weight bearing; T-gel did not cause any changes in both the weight load and PWT. In OA rats, T-gel at 20 L had a significant analgesic effect for 2 days, even though T-gel at 50 L further reduced the weight load, demonstrating that intra-articular T-gel (20 L) has long-lasting analgesic effects in OA rats. Thus, T-gel designed to deliver analgesics into the joint cavity could be an effective therapeutic tool in the clinical setting.

Original languageEnglish
Article number812949
JournalBioMed Research International
Publication statusPublished - 2015


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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