Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women

Renée T. Fortner, Hannah Oh, Sarah E. Daugherty, Xia Xu, Susan E. Hankinson, Regina G. Ziegler, A. Heather Eliassen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Analgesic use has been hypothesized to reduce the risk of some cancers, with inverse associations between analgesics and colon cancer, and suggestive inverse associations for breast cancer. Estrogen metabolites (EM) have genotoxic and estrogenic potential; genotoxicity may differ by hydroxylation pathway. Analgesic use may impact patterns of estrogen metabolism; effects of analgesics on disease risk could be mediated through these patterns. We conducted a cross-sectional study among 603 premenopausal women in the Nurses' Health Study II. Frequency of aspirin, non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen use was reported via questionnaire; average frequency in 1997 and 1999 was calculated. Women provided urine samples between 1996 and 1999, collected during the mid-luteal phase of the menstrual cycle. Urinary EM were quantified using high-performance liquid chromatography-tandem mass spectrometry. We observed no association between analgesic use and estradiol, estrone, or specific pathways of estrogen metabolism. Women reporting more frequent aspirin use had lower methylated 2-catechols (e.g., 2-hydroxyestrone-3-methyl ether, 2+ days/week vs. non-use: 0.95 vs. 1.21 pmol/mg creatinine; pdifference = 0.01, ptrend = 0.07). Non-aspirin NSAID use was positively associated with 17-epiestriol (4+ days/week vs. non-use: 2.48 vs. 1.52 pmol/mg creatinine; pdifference = 0.01, ptrend = 0.11). Acetaminophen use was positively associated with total EM (2+ days/week vs. non-use: 236 vs. 198 pmol/mg creatinine; pdifference = 0.02, ptrend = 0.11), 2-hydroxyestrone-3-methyl ether (1.6 vs. 1.1 pmol/mg creatinine; pdifference < 0.01, ptrend = 0.02), and 16α-hydroxyestrone (17 vs. 12 pmol/mg creatinine; pdifference = 0.01, ptrend = 0.05). This study provides the first assessment of analgesic use and patterns of estrogen metabolism in women. While we observed some associations between analgesics and individual EM, no clear patterns emerged.

Original languageEnglish
Pages (from-to)104-112
Number of pages9
JournalHormones and Cancer
Volume5
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Analgesics
Estrogens
Creatinine
Methyl Ethers
Acetaminophen
Aspirin
Anti-Inflammatory Agents
Catechols
Estriol
Estrone
Luteal Phase
Hydroxylation
Tandem Mass Spectrometry
Pharmaceutical Preparations
Colonic Neoplasms
Estradiol
Cross-Sectional Studies
Nurses
High Pressure Liquid Chromatography
Urine

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cancer Research

Cite this

Fortner, R. T., Oh, H., Daugherty, S. E., Xu, X., Hankinson, S. E., Ziegler, R. G., & Eliassen, A. H. (2014). Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women. Hormones and Cancer, 5(2), 104-112. https://doi.org/10.1007/s12672-013-0167-5

Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women. / Fortner, Renée T.; Oh, Hannah; Daugherty, Sarah E.; Xu, Xia; Hankinson, Susan E.; Ziegler, Regina G.; Eliassen, A. Heather.

In: Hormones and Cancer, Vol. 5, No. 2, 01.01.2014, p. 104-112.

Research output: Contribution to journalArticle

Fortner, RT, Oh, H, Daugherty, SE, Xu, X, Hankinson, SE, Ziegler, RG & Eliassen, AH 2014, 'Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women', Hormones and Cancer, vol. 5, no. 2, pp. 104-112. https://doi.org/10.1007/s12672-013-0167-5
Fortner RT, Oh H, Daugherty SE, Xu X, Hankinson SE, Ziegler RG et al. Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women. Hormones and Cancer. 2014 Jan 1;5(2):104-112. https://doi.org/10.1007/s12672-013-0167-5
Fortner, Renée T. ; Oh, Hannah ; Daugherty, Sarah E. ; Xu, Xia ; Hankinson, Susan E. ; Ziegler, Regina G. ; Eliassen, A. Heather. / Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women. In: Hormones and Cancer. 2014 ; Vol. 5, No. 2. pp. 104-112.
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