Analysis for the potential of polystyrene and TiO 2 nanoparticles to induce skin irritation, phototoxicity, and sensitization

Yoon Hee Park, Sang Hoon Jeong, Sang Min Yi, Byeong Hyeok Choi, Yu Ri Kim, In Kyoung Kim, Meyoung Kon Kim, Sang Wook Son

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The human skin equivalent model (HSEM) is well known as an attractive alternative model for evaluation of dermal toxicity. However, only limited data are available on the usefulness of a HSEM for nanotoxicity testing. This study was designed to investigate cutaneous toxicity of polystyrene and TiO 2 nanoparticles using cultured keratinocytes, a HSEM, and an animal model. In addition, we also evaluated the skin sensitization potential of nanoparticles using a local lymph node assay with incorporation of BrdU. Findings from the present study indicate that polystyrene and TiO 2 nanoparticles do not induce phototoxicity, acute cutaneous irritation, or skin sensitization. Results from evaluation of the HSEMs correspond well with those from animal models. Our findings suggest that the HSEM might be a useful alternative model for evaluation of dermal nanotoxicity.

Original languageEnglish
Pages (from-to)1863-1869
Number of pages7
JournalToxicology in Vitro
Volume25
Issue number8
DOIs
Publication statusPublished - 2011 Dec 1

Keywords

  • Phototoxicity
  • Polystyrene
  • Skin irritation
  • Skin sensitization
  • TiO

ASJC Scopus subject areas

  • Toxicology

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