Analysis for the potential of polystyrene and TiO 2 nanoparticles to induce skin irritation, phototoxicity, and sensitization

Yoon Hee Park, Sang Hoon Jeong, Sang Min Yi, Byeong Hyeok Choi, Yu Ri Kim, In Kyoung Kim, Meyoung-Kon Kim, Sang Wook Son

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The human skin equivalent model (HSEM) is well known as an attractive alternative model for evaluation of dermal toxicity. However, only limited data are available on the usefulness of a HSEM for nanotoxicity testing. This study was designed to investigate cutaneous toxicity of polystyrene and TiO 2 nanoparticles using cultured keratinocytes, a HSEM, and an animal model. In addition, we also evaluated the skin sensitization potential of nanoparticles using a local lymph node assay with incorporation of BrdU. Findings from the present study indicate that polystyrene and TiO 2 nanoparticles do not induce phototoxicity, acute cutaneous irritation, or skin sensitization. Results from evaluation of the HSEMs correspond well with those from animal models. Our findings suggest that the HSEM might be a useful alternative model for evaluation of dermal nanotoxicity.

Original languageEnglish
Pages (from-to)1863-1869
Number of pages7
JournalToxicology in Vitro
Volume25
Issue number8
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Phototoxic Dermatitis
Polystyrenes
Nanoparticles
Skin
Toxicity
Animals
Local Lymph Node Assay
Animal Models
Bromodeoxyuridine
Assays
Keratinocytes
Testing

Keywords

  • Phototoxicity
  • Polystyrene
  • Skin irritation
  • Skin sensitization
  • TiO

ASJC Scopus subject areas

  • Toxicology

Cite this

Analysis for the potential of polystyrene and TiO 2 nanoparticles to induce skin irritation, phototoxicity, and sensitization. / Park, Yoon Hee; Jeong, Sang Hoon; Yi, Sang Min; Choi, Byeong Hyeok; Kim, Yu Ri; Kim, In Kyoung; Kim, Meyoung-Kon; Son, Sang Wook.

In: Toxicology in Vitro, Vol. 25, No. 8, 01.12.2011, p. 1863-1869.

Research output: Contribution to journalArticle

Park, Yoon Hee ; Jeong, Sang Hoon ; Yi, Sang Min ; Choi, Byeong Hyeok ; Kim, Yu Ri ; Kim, In Kyoung ; Kim, Meyoung-Kon ; Son, Sang Wook. / Analysis for the potential of polystyrene and TiO 2 nanoparticles to induce skin irritation, phototoxicity, and sensitization. In: Toxicology in Vitro. 2011 ; Vol. 25, No. 8. pp. 1863-1869.
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