Analysis of anticancer activity and chemical sensitization effects of dendropanax morbifera and commersonia bartramia extracts

K. I.M. Seongmin; Sung G.Y.U. Park; Yoon J.A.E. Song; Jeong K.O.O. Park; Cheol H.E.E. Choi; L. E.E. Sanghoon; Robert M. Hoffman

doi:10.21873/anticanres.12669

Analysis of anticancer activity and chemical sensitization effects of dendropanax morbifera and commersonia bartramia extracts

K. I.M. Seongmin, Sung G.Y.U. Park, Yoon J.A.E. Song, Jeong K.O.O. Park, Cheol H.E.E. Choi, L. E.E. Sanghoon, Robert M. Hoffman

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background/Aim: Dendropanax morbifera (DM) and Commersonia bartramia (CB) are possible candidates for immunotherapy. In this study, the cytotoxicity and chemical sensitization of DM and CB extracts on gynecologic and colon cancers were evaluated. Materials and Methods: The malignant cell lines were cultured and analyzed for cytotoxicity and chemical sensitization. A mouse model was also constructed to make the condition similar to in vivo. Reverse transcription-polymerase chain reaction was conducted to determine alterations in drug-resistant genes. Results: The extracts from DM and CB showed specific cytotoxicity to malignant cell lines. DM increased chemical sensitivity to cervical and ovarian cancer, while CB showed improved sensitization to endometrial cancer. The effects of the extracts were confirmed using a mouse model. The extracts induced differences in the expression levels of a number of genes related to drug resistance. Conclusion: DM and CB extracts could be novel agents for immunotherapy and chemical sensitization in gynecologic and colon cancers.

Original language	English
Pages (from-to)	3853-3861
Number of pages	9
Journal	Anticancer research
Volume	38
Issue number	7
DOIs	https://doi.org/10.21873/anticanres.12669
Publication status	Published - 2018 Jul

Keywords

Chemical sensitivity
Commersonia
Cytotoxicity
Dendropanax
Drug response

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.12669

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@article{cda71b24977c4f6897a51dec3a1321a1,

title = "Analysis of anticancer activity and chemical sensitization effects of dendropanax morbifera and commersonia bartramia extracts",

abstract = "Background/Aim: Dendropanax morbifera (DM) and Commersonia bartramia (CB) are possible candidates for immunotherapy. In this study, the cytotoxicity and chemical sensitization of DM and CB extracts on gynecologic and colon cancers were evaluated. Materials and Methods: The malignant cell lines were cultured and analyzed for cytotoxicity and chemical sensitization. A mouse model was also constructed to make the condition similar to in vivo. Reverse transcription-polymerase chain reaction was conducted to determine alterations in drug-resistant genes. Results: The extracts from DM and CB showed specific cytotoxicity to malignant cell lines. DM increased chemical sensitivity to cervical and ovarian cancer, while CB showed improved sensitization to endometrial cancer. The effects of the extracts were confirmed using a mouse model. The extracts induced differences in the expression levels of a number of genes related to drug resistance. Conclusion: DM and CB extracts could be novel agents for immunotherapy and chemical sensitization in gynecologic and colon cancers.",

keywords = "Chemical sensitivity, Commersonia, Cytotoxicity, Dendropanax, Drug response",

author = "Seongmin, {K. I.M.} and Park, {Sung G.Y.U.} and Song, {Yoon J.A.E.} and Park, {Jeong K.O.O.} and Choi, {Cheol H.E.E.} and Sanghoon, {L. E.E.} and Hoffman, {Robert M.}",

note = "Funding Information: This study was supported by the National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B3015250) and Korea University Grant (K1620191). Publisher Copyright: {\textcopyright} 2018 International Institute of Anticancer Research. All rights reserved.",

year = "2018",

month = jul,

doi = "10.21873/anticanres.12669",

language = "English",

volume = "38",

pages = "3853--3861",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "7",

}

TY - JOUR

T1 - Analysis of anticancer activity and chemical sensitization effects of dendropanax morbifera and commersonia bartramia extracts

AU - Seongmin, K. I.M.

AU - Park, Sung G.Y.U.

AU - Song, Yoon J.A.E.

AU - Park, Jeong K.O.O.

AU - Choi, Cheol H.E.E.

AU - Sanghoon, L. E.E.

AU - Hoffman, Robert M.

N1 - Funding Information: This study was supported by the National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1C1B3015250) and Korea University Grant (K1620191). Publisher Copyright: © 2018 International Institute of Anticancer Research. All rights reserved.

PY - 2018/7

Y1 - 2018/7

N2 - Background/Aim: Dendropanax morbifera (DM) and Commersonia bartramia (CB) are possible candidates for immunotherapy. In this study, the cytotoxicity and chemical sensitization of DM and CB extracts on gynecologic and colon cancers were evaluated. Materials and Methods: The malignant cell lines were cultured and analyzed for cytotoxicity and chemical sensitization. A mouse model was also constructed to make the condition similar to in vivo. Reverse transcription-polymerase chain reaction was conducted to determine alterations in drug-resistant genes. Results: The extracts from DM and CB showed specific cytotoxicity to malignant cell lines. DM increased chemical sensitivity to cervical and ovarian cancer, while CB showed improved sensitization to endometrial cancer. The effects of the extracts were confirmed using a mouse model. The extracts induced differences in the expression levels of a number of genes related to drug resistance. Conclusion: DM and CB extracts could be novel agents for immunotherapy and chemical sensitization in gynecologic and colon cancers.

AB - Background/Aim: Dendropanax morbifera (DM) and Commersonia bartramia (CB) are possible candidates for immunotherapy. In this study, the cytotoxicity and chemical sensitization of DM and CB extracts on gynecologic and colon cancers were evaluated. Materials and Methods: The malignant cell lines were cultured and analyzed for cytotoxicity and chemical sensitization. A mouse model was also constructed to make the condition similar to in vivo. Reverse transcription-polymerase chain reaction was conducted to determine alterations in drug-resistant genes. Results: The extracts from DM and CB showed specific cytotoxicity to malignant cell lines. DM increased chemical sensitivity to cervical and ovarian cancer, while CB showed improved sensitization to endometrial cancer. The effects of the extracts were confirmed using a mouse model. The extracts induced differences in the expression levels of a number of genes related to drug resistance. Conclusion: DM and CB extracts could be novel agents for immunotherapy and chemical sensitization in gynecologic and colon cancers.

KW - Chemical sensitivity

KW - Commersonia

KW - Cytotoxicity

KW - Dendropanax

KW - Drug response

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U2 - 10.21873/anticanres.12669

DO - 10.21873/anticanres.12669

M3 - Article

C2 - 29970505

AN - SCOPUS:85049789770

SN - 0250-7005

VL - 38

SP - 3853

EP - 3861

JO - Anticancer Research

JF - Anticancer Research

IS - 7

ER -

Analysis of anticancer activity and chemical sensitization effects of dendropanax morbifera and commersonia bartramia extracts

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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