Analysis of lower limb bradykinesia in Parkinson's disease patients

Ji Won Kim, Yuri Kwon, Yu Mi Kim, Hong Young Chung, Gwang Moon Eom, Jae Hoon Jun, Jeong Whan Lee, Seong Beom Koh, Byung Kyu Park, Dae Kyu Kwon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aim: Bradykinesia of the lower limb is an important limiting factor of the quality of life in parkinsonian patients. This study aims to develop quantitative measures of bradykinesia and to investigate the possible dissociation of amplitude and velocity measures and their dependence on movement direction during toe-tapping. Methods: Subjects included 39 patients with PD, as well as 14 healthy control subjects. A gyrosensor on the dorsum of a foot was used to measure ankle joint movement during toe-tapping. Four representations (root-mean square, mean peak, coefficient of variation in peaks, peak in the last 5s) for each of amplitude and velocity and for each of plantar flexion and dorsiflexion movement of toe-tapping were investigated. Outcome measures were compared between patients and controls, and their correlations with clinical scores were investigated. Category distributions of outcome measures in patients were analyzed. Results: All outcome measures were smaller in patients than in controls (P<0.001) and correlated well with clinical scores (P<0.01). The mean peak of plantar-flexion velocity and variation of dorsiflexion velocity best represented the clinical toe-tapping score (r=0.72-0.81). All clinical scores showed better correlation with velocity than with amplitude, and velocity was more affected (dispersed from the performance of controls) than amplitude. Movement directions had a slight effect on the results; specifically, the magnitude measures better correlated during plantar flexion and the variation measure better correlated during dorsiflexion. Conclusion: The suggested measures represented clinical scores well and are expected to be helpful in clinical diagnosis of lower limb bradykinesia. Possible dissociations of amplitude and speed impairments and of movement directions in PD deserve further investigation.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalGeriatrics and Gerontology International
Volume12
Issue number2
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

Hypokinesia
Parkinson Disease
Toes
Lower Extremity
Disease
Outcome Assessment (Health Care)
Ankle Joint
Foot
Healthy Volunteers
quality of life
Quality of Life
performance
Direction compound

Keywords

  • Lower limb bradykinesia
  • Parkinson's disease
  • Quantification
  • Toe-tapping
  • UPDRS

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)

Cite this

Kim, J. W., Kwon, Y., Kim, Y. M., Chung, H. Y., Eom, G. M., Jun, J. H., ... Kwon, D. K. (2012). Analysis of lower limb bradykinesia in Parkinson's disease patients. Geriatrics and Gerontology International, 12(2), 257-264. https://doi.org/10.1111/j.1447-0594.2011.00761.x

Analysis of lower limb bradykinesia in Parkinson's disease patients. / Kim, Ji Won; Kwon, Yuri; Kim, Yu Mi; Chung, Hong Young; Eom, Gwang Moon; Jun, Jae Hoon; Lee, Jeong Whan; Koh, Seong Beom; Park, Byung Kyu; Kwon, Dae Kyu.

In: Geriatrics and Gerontology International, Vol. 12, No. 2, 01.04.2012, p. 257-264.

Research output: Contribution to journalArticle

Kim, JW, Kwon, Y, Kim, YM, Chung, HY, Eom, GM, Jun, JH, Lee, JW, Koh, SB, Park, BK & Kwon, DK 2012, 'Analysis of lower limb bradykinesia in Parkinson's disease patients', Geriatrics and Gerontology International, vol. 12, no. 2, pp. 257-264. https://doi.org/10.1111/j.1447-0594.2011.00761.x
Kim, Ji Won ; Kwon, Yuri ; Kim, Yu Mi ; Chung, Hong Young ; Eom, Gwang Moon ; Jun, Jae Hoon ; Lee, Jeong Whan ; Koh, Seong Beom ; Park, Byung Kyu ; Kwon, Dae Kyu. / Analysis of lower limb bradykinesia in Parkinson's disease patients. In: Geriatrics and Gerontology International. 2012 ; Vol. 12, No. 2. pp. 257-264.
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