Anamorsin, a novel caspase-3 substrate in neurodegeneration

Nuri Yun, Young Mook Lee, Chiho Kim, Hirohiko Shibayama, Akira Tanimura, Yuri Hamanaka, Yuzuru Kanakura, Il Seon Park, Areum Jo, Joo Ho Shin, Chung Ju, Won-Ki Kim, Young J. Oh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

Original languageEnglish
Pages (from-to)22183-22195
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
Publication statusPublished - 2014 Aug 8

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Caspase 3
Substrates
Neurology
Cell death
Cell Death
Central Nervous System

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Yun, N., Lee, Y. M., Kim, C., Shibayama, H., Tanimura, A., Hamanaka, Y., ... Oh, Y. J. (2014). Anamorsin, a novel caspase-3 substrate in neurodegeneration. Journal of Biological Chemistry, 289(32), 22183-22195. https://doi.org/10.1074/jbc.M114.552679

Anamorsin, a novel caspase-3 substrate in neurodegeneration. / Yun, Nuri; Lee, Young Mook; Kim, Chiho; Shibayama, Hirohiko; Tanimura, Akira; Hamanaka, Yuri; Kanakura, Yuzuru; Park, Il Seon; Jo, Areum; Shin, Joo Ho; Ju, Chung; Kim, Won-Ki; Oh, Young J.

In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22183-22195.

Research output: Contribution to journalArticle

Yun, N, Lee, YM, Kim, C, Shibayama, H, Tanimura, A, Hamanaka, Y, Kanakura, Y, Park, IS, Jo, A, Shin, JH, Ju, C, Kim, W-K & Oh, YJ 2014, 'Anamorsin, a novel caspase-3 substrate in neurodegeneration', Journal of Biological Chemistry, vol. 289, no. 32, pp. 22183-22195. https://doi.org/10.1074/jbc.M114.552679
Yun N, Lee YM, Kim C, Shibayama H, Tanimura A, Hamanaka Y et al. Anamorsin, a novel caspase-3 substrate in neurodegeneration. Journal of Biological Chemistry. 2014 Aug 8;289(32):22183-22195. https://doi.org/10.1074/jbc.M114.552679
Yun, Nuri ; Lee, Young Mook ; Kim, Chiho ; Shibayama, Hirohiko ; Tanimura, Akira ; Hamanaka, Yuri ; Kanakura, Yuzuru ; Park, Il Seon ; Jo, Areum ; Shin, Joo Ho ; Ju, Chung ; Kim, Won-Ki ; Oh, Young J. / Anamorsin, a novel caspase-3 substrate in neurodegeneration. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 32. pp. 22183-22195.
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