Anamorsin, a novel caspase-3 substrate in neurodegeneration

Nuri Yun, Young Mook Lee, Chiho Kim, Hirohiko Shibayama, Akira Tanimura, Yuri Hamanaka, Yuzuru Kanakura, Il Seon Park, Areum Jo, Joo Ho Shin, Chung Ju, Won-Ki Kim, Young J. Oh

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9 Citations (Scopus)

Abstract

Background: It is crucial to identify caspase-3 substrates and their roles during neurodegeneration. Results: Our approach identified 46 novel substrates. Furthermore, we found that anamorsin was cleaved by caspase-3 and mapped its cleavage site. Conclusion: Anamorsin may play an antiapoptotic role in the central nervous system. Significance: Our findings contribute to understanding the molecular mechanism underlying role for anamorsin in caspase-3- mediated cell death.

Original languageEnglish
Pages (from-to)22183-22195
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
Publication statusPublished - 2014 Aug 8

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Yun, N., Lee, Y. M., Kim, C., Shibayama, H., Tanimura, A., Hamanaka, Y., Kanakura, Y., Park, I. S., Jo, A., Shin, J. H., Ju, C., Kim, W-K., & Oh, Y. J. (2014). Anamorsin, a novel caspase-3 substrate in neurodegeneration. Journal of Biological Chemistry, 289(32), 22183-22195. https://doi.org/10.1074/jbc.M114.552679