Anemia as a clinical marker of stable chronic obstructive pulmonary disease in the Korean obstructive lung disease cohort

Yeon Mok Oh, Joo Hun Park, Eun Kyung Kim, Sung Chul Hwang, Hyun Ji Kim, Dae Ryong Kang, Kwang Ha Yoo, Ji Hyun Lee, Tae Hyung Kim, Seong Yong Lim, Chin Kook Rhee, Hyoung Kyu Yoon, Sang Yeub Lee, Sang Do Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Anemia is a major co-morbidity in chronic obstructive pulmonary disease (COPD). However, the mechanism of development for anemia and the impact of anemia on the prognosis of COPD remain poorly understood. Therefore, this study attempted to evaluate the prognostic role of anemia on the clinical course of COPD and investigate the factors linked with the serum hemoglobin level in COPD. Methods: We analyzed 407 COPD patients enrolled in the Korean obstructive lung disease (KOLD) cohort at 16 hospitals in Korea recruited over 9 years. Multivariate Cox regression analysis was performed to find independent predictors of survival and multivariate logistic regression analyses were done to find independent factors. Results: Anemic COPD were older with lower body mass index (BMI) (P < 0.001), lower serum cholesterol level (P=0.001), lower serum albumin level (P < 0.001), and shorter 6-minute walking distance (P=0.046) compared to non-anemic COPD. A multivariate Cox regression analysis revealed that age (P=0.002), BMI (P=0.001), post-bronchodilator forced expiratory volume in 1 second (FEV1) (P=0.007), 6-minute walk distance (P=0.008), anemia (P=0.025) were significant predictors for all-cause mortality. In multivariate regression analysis, older age (P < 0.001), female gender (P=0.001), lower BMI (P=0.016), and lower serum albumin level (P < 0.001) were independent factors associated with lower serum hemoglobin level. Conclusions: Our data showed that anemia was an independent risk factor for mortality in COPD, and aging, lower serum albumin level, and lower BMI were independent factors associated with lower serum hemoglobin level.

Original languageEnglish
Pages (from-to)5008-5016
Number of pages9
JournalJournal of Thoracic Disease
Volume9
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1

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Obstructive Lung Diseases
Chronic Obstructive Pulmonary Disease
Anemia
Biomarkers
Body Mass Index
Regression Analysis
Serum Albumin
Hemoglobins
Serum
Mortality
Bronchodilator Agents
Forced Expiratory Volume
Korea
Walking
Multivariate Analysis
Logistic Models
Cholesterol
Morbidity
Survival

Keywords

  • Anemia
  • Chronic obstructive pulmonary disease (COPD)
  • Clinical marker

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Anemia as a clinical marker of stable chronic obstructive pulmonary disease in the Korean obstructive lung disease cohort. / Oh, Yeon Mok; Park, Joo Hun; Kim, Eun Kyung; Hwang, Sung Chul; Kim, Hyun Ji; Kang, Dae Ryong; Yoo, Kwang Ha; Lee, Ji Hyun; Kim, Tae Hyung; Lim, Seong Yong; Rhee, Chin Kook; Yoon, Hyoung Kyu; Lee, Sang Yeub; Lee, Sang Do.

In: Journal of Thoracic Disease, Vol. 9, No. 12, 01.12.2017, p. 5008-5016.

Research output: Contribution to journalArticle

Oh, YM, Park, JH, Kim, EK, Hwang, SC, Kim, HJ, Kang, DR, Yoo, KH, Lee, JH, Kim, TH, Lim, SY, Rhee, CK, Yoon, HK, Lee, SY & Lee, SD 2017, 'Anemia as a clinical marker of stable chronic obstructive pulmonary disease in the Korean obstructive lung disease cohort', Journal of Thoracic Disease, vol. 9, no. 12, pp. 5008-5016. https://doi.org/10.21037/jtd.2017.10.140
Oh, Yeon Mok ; Park, Joo Hun ; Kim, Eun Kyung ; Hwang, Sung Chul ; Kim, Hyun Ji ; Kang, Dae Ryong ; Yoo, Kwang Ha ; Lee, Ji Hyun ; Kim, Tae Hyung ; Lim, Seong Yong ; Rhee, Chin Kook ; Yoon, Hyoung Kyu ; Lee, Sang Yeub ; Lee, Sang Do. / Anemia as a clinical marker of stable chronic obstructive pulmonary disease in the Korean obstructive lung disease cohort. In: Journal of Thoracic Disease. 2017 ; Vol. 9, No. 12. pp. 5008-5016.
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abstract = "Background: Anemia is a major co-morbidity in chronic obstructive pulmonary disease (COPD). However, the mechanism of development for anemia and the impact of anemia on the prognosis of COPD remain poorly understood. Therefore, this study attempted to evaluate the prognostic role of anemia on the clinical course of COPD and investigate the factors linked with the serum hemoglobin level in COPD. Methods: We analyzed 407 COPD patients enrolled in the Korean obstructive lung disease (KOLD) cohort at 16 hospitals in Korea recruited over 9 years. Multivariate Cox regression analysis was performed to find independent predictors of survival and multivariate logistic regression analyses were done to find independent factors. Results: Anemic COPD were older with lower body mass index (BMI) (P < 0.001), lower serum cholesterol level (P=0.001), lower serum albumin level (P < 0.001), and shorter 6-minute walking distance (P=0.046) compared to non-anemic COPD. A multivariate Cox regression analysis revealed that age (P=0.002), BMI (P=0.001), post-bronchodilator forced expiratory volume in 1 second (FEV1) (P=0.007), 6-minute walk distance (P=0.008), anemia (P=0.025) were significant predictors for all-cause mortality. In multivariate regression analysis, older age (P < 0.001), female gender (P=0.001), lower BMI (P=0.016), and lower serum albumin level (P < 0.001) were independent factors associated with lower serum hemoglobin level. Conclusions: Our data showed that anemia was an independent risk factor for mortality in COPD, and aging, lower serum albumin level, and lower BMI were independent factors associated with lower serum hemoglobin level.",
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T1 - Anemia as a clinical marker of stable chronic obstructive pulmonary disease in the Korean obstructive lung disease cohort

AU - Oh, Yeon Mok

AU - Park, Joo Hun

AU - Kim, Eun Kyung

AU - Hwang, Sung Chul

AU - Kim, Hyun Ji

AU - Kang, Dae Ryong

AU - Yoo, Kwang Ha

AU - Lee, Ji Hyun

AU - Kim, Tae Hyung

AU - Lim, Seong Yong

AU - Rhee, Chin Kook

AU - Yoon, Hyoung Kyu

AU - Lee, Sang Yeub

AU - Lee, Sang Do

PY - 2017/12/1

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N2 - Background: Anemia is a major co-morbidity in chronic obstructive pulmonary disease (COPD). However, the mechanism of development for anemia and the impact of anemia on the prognosis of COPD remain poorly understood. Therefore, this study attempted to evaluate the prognostic role of anemia on the clinical course of COPD and investigate the factors linked with the serum hemoglobin level in COPD. Methods: We analyzed 407 COPD patients enrolled in the Korean obstructive lung disease (KOLD) cohort at 16 hospitals in Korea recruited over 9 years. Multivariate Cox regression analysis was performed to find independent predictors of survival and multivariate logistic regression analyses were done to find independent factors. Results: Anemic COPD were older with lower body mass index (BMI) (P < 0.001), lower serum cholesterol level (P=0.001), lower serum albumin level (P < 0.001), and shorter 6-minute walking distance (P=0.046) compared to non-anemic COPD. A multivariate Cox regression analysis revealed that age (P=0.002), BMI (P=0.001), post-bronchodilator forced expiratory volume in 1 second (FEV1) (P=0.007), 6-minute walk distance (P=0.008), anemia (P=0.025) were significant predictors for all-cause mortality. In multivariate regression analysis, older age (P < 0.001), female gender (P=0.001), lower BMI (P=0.016), and lower serum albumin level (P < 0.001) were independent factors associated with lower serum hemoglobin level. Conclusions: Our data showed that anemia was an independent risk factor for mortality in COPD, and aging, lower serum albumin level, and lower BMI were independent factors associated with lower serum hemoglobin level.

AB - Background: Anemia is a major co-morbidity in chronic obstructive pulmonary disease (COPD). However, the mechanism of development for anemia and the impact of anemia on the prognosis of COPD remain poorly understood. Therefore, this study attempted to evaluate the prognostic role of anemia on the clinical course of COPD and investigate the factors linked with the serum hemoglobin level in COPD. Methods: We analyzed 407 COPD patients enrolled in the Korean obstructive lung disease (KOLD) cohort at 16 hospitals in Korea recruited over 9 years. Multivariate Cox regression analysis was performed to find independent predictors of survival and multivariate logistic regression analyses were done to find independent factors. Results: Anemic COPD were older with lower body mass index (BMI) (P < 0.001), lower serum cholesterol level (P=0.001), lower serum albumin level (P < 0.001), and shorter 6-minute walking distance (P=0.046) compared to non-anemic COPD. A multivariate Cox regression analysis revealed that age (P=0.002), BMI (P=0.001), post-bronchodilator forced expiratory volume in 1 second (FEV1) (P=0.007), 6-minute walk distance (P=0.008), anemia (P=0.025) were significant predictors for all-cause mortality. In multivariate regression analysis, older age (P < 0.001), female gender (P=0.001), lower BMI (P=0.016), and lower serum albumin level (P < 0.001) were independent factors associated with lower serum hemoglobin level. Conclusions: Our data showed that anemia was an independent risk factor for mortality in COPD, and aging, lower serum albumin level, and lower BMI were independent factors associated with lower serum hemoglobin level.

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KW - Chronic obstructive pulmonary disease (COPD)

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