Angiogenesis imaging in myocardial infarction using 68Ga-NOTA- RGD PET: Characterization and application to therapeutic efficacy monitoring in rats

Jae Seon Eo, Jin Chul Paeng, Song Lee, Yun Sang Lee, Jae Min Jeong, Keon Wook Kang, June Key Chung, Dong Soo Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: 68Ga-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, 68Ga-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. MATERIALS AND METHODS: 68Ga-NOTA-RGD PET was performed serially in rats with MI or sham operation, and myocardial uptake was analyzed with respect to time duration and tissue characteristics. Subsequently, Ga-NOTA-RGD PET was serially performed for therapeutic efficacy monitoring in MI-induced rats, which were treated with basic fibroblast growth factor (bFGF) injection or saline injection. Image findings were compared with the final change in MI lesion. RESULTS: 68Ga-NOTA-RGD uptake was significantly increased in MI lesion and gradually decreased over time. 68Ga-NOTA-RGD uptake in the infarcted tissue corresponded with vascular endothelial growth factor expression and macrophage accumulation. In monitoring of therapeutic efficacy, the lesion uptake in the bFGF-injected group was significantly higher than that of the saline-injected and sham-operated groups on the first day. However, no significant differences were observed between bFGF and saline-injected groups at subsequent time points, corresponding to the final infarct size change. CONCLUSION: 68Ga-NOTA-RGD PET would be a useful angiogenesis imaging modality in MI for assessment of pathophysiology or monitoring of therapeutic efficacy.

Original languageEnglish
Pages (from-to)303-311
Number of pages9
JournalCoronary Artery Disease
Volume24
Issue number4
DOIs
Publication statusPublished - 2013 Jun 1

Fingerprint

Myocardial Infarction
Fibroblast Growth Factor 2
Therapeutics
Injections
Molecular Imaging
Vascular Endothelial Growth Factor A
68Ga-1,4,7-triazacyclononane-1,4-7-triacetic acid-isothiocyanatobenzyl-c(Arg-Gly-Asp-Tyr-Lys)
Macrophages

Keywords

  • Ga
  • Myocardial infarction
  • PET
  • RGD peptide
  • Therapeutic angiogenesis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Angiogenesis imaging in myocardial infarction using 68Ga-NOTA- RGD PET : Characterization and application to therapeutic efficacy monitoring in rats. / Eo, Jae Seon; Paeng, Jin Chul; Lee, Song; Lee, Yun Sang; Jeong, Jae Min; Kang, Keon Wook; Chung, June Key; Lee, Dong Soo.

In: Coronary Artery Disease, Vol. 24, No. 4, 01.06.2013, p. 303-311.

Research output: Contribution to journalArticle

Eo, Jae Seon ; Paeng, Jin Chul ; Lee, Song ; Lee, Yun Sang ; Jeong, Jae Min ; Kang, Keon Wook ; Chung, June Key ; Lee, Dong Soo. / Angiogenesis imaging in myocardial infarction using 68Ga-NOTA- RGD PET : Characterization and application to therapeutic efficacy monitoring in rats. In: Coronary Artery Disease. 2013 ; Vol. 24, No. 4. pp. 303-311.
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AU - Lee, Yun Sang

AU - Jeong, Jae Min

AU - Kang, Keon Wook

AU - Chung, June Key

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N2 - OBJECTIVE: 68Ga-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, 68Ga-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. MATERIALS AND METHODS: 68Ga-NOTA-RGD PET was performed serially in rats with MI or sham operation, and myocardial uptake was analyzed with respect to time duration and tissue characteristics. Subsequently, Ga-NOTA-RGD PET was serially performed for therapeutic efficacy monitoring in MI-induced rats, which were treated with basic fibroblast growth factor (bFGF) injection or saline injection. Image findings were compared with the final change in MI lesion. RESULTS: 68Ga-NOTA-RGD uptake was significantly increased in MI lesion and gradually decreased over time. 68Ga-NOTA-RGD uptake in the infarcted tissue corresponded with vascular endothelial growth factor expression and macrophage accumulation. In monitoring of therapeutic efficacy, the lesion uptake in the bFGF-injected group was significantly higher than that of the saline-injected and sham-operated groups on the first day. However, no significant differences were observed between bFGF and saline-injected groups at subsequent time points, corresponding to the final infarct size change. CONCLUSION: 68Ga-NOTA-RGD PET would be a useful angiogenesis imaging modality in MI for assessment of pathophysiology or monitoring of therapeutic efficacy.

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