Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

Junghyo Yoon, Nuriye Korkmaz Zirpel, Hyun Ji Park, Sewoon Han, Kyung Hoon Hwang, Jisoo Shin, Seung Woo Cho, Chang Hoon Nam, Seok Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)


Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalAdvanced healthcare materials
Issue number2
Publication statusPublished - 2016 Jan 1



  • Angiogenesis
  • Bacteriophages
  • Collagen
  • Growth factors, VEGF

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science

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