Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

Junghyo Yoon, Nuriye Korkmaz Zirpel, Hyun Ji Park, Sewoon Han, Kyung Hoon Hwang, Jisoo Shin, Seung Woo Cho, Chang Hoon Nam, Seok Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalAdvanced healthcare materials
Volume5
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Vascular Endothelial Growth Factors
Bacteriophages
Collagen Type I
Collagen
Vascular Endothelial Growth Factor A
Extracellular Matrix
Nanofibers
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Endothelial cells
Gelation

Keywords

  • Angiogenesis
  • Bacteriophages
  • Collagen
  • Growth factors, VEGF

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science

Cite this

Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors. / Yoon, Junghyo; Korkmaz Zirpel, Nuriye; Park, Hyun Ji; Han, Sewoon; Hwang, Kyung Hoon; Shin, Jisoo; Cho, Seung Woo; Nam, Chang Hoon; Chung, Seok.

In: Advanced healthcare materials, Vol. 5, No. 2, 01.01.2016, p. 205-212.

Research output: Contribution to journalArticle

Yoon, Junghyo ; Korkmaz Zirpel, Nuriye ; Park, Hyun Ji ; Han, Sewoon ; Hwang, Kyung Hoon ; Shin, Jisoo ; Cho, Seung Woo ; Nam, Chang Hoon ; Chung, Seok. / Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors. In: Advanced healthcare materials. 2016 ; Vol. 5, No. 2. pp. 205-212.
@article{2ef32b248c0249a0baf5fe7f3ae053c6,
title = "Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors",
abstract = "Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.",
keywords = "Angiogenesis, Bacteriophages, Collagen, Growth factors, VEGF",
author = "Junghyo Yoon and {Korkmaz Zirpel}, Nuriye and Park, {Hyun Ji} and Sewoon Han and Hwang, {Kyung Hoon} and Jisoo Shin and Cho, {Seung Woo} and Nam, {Chang Hoon} and Seok Chung",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/adhm.201500534",
language = "English",
volume = "5",
pages = "205--212",
journal = "Advanced healthcare materials",
issn = "2192-2640",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors

AU - Yoon, Junghyo

AU - Korkmaz Zirpel, Nuriye

AU - Park, Hyun Ji

AU - Han, Sewoon

AU - Hwang, Kyung Hoon

AU - Shin, Jisoo

AU - Cho, Seung Woo

AU - Nam, Chang Hoon

AU - Chung, Seok

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.

AB - Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix.

KW - Angiogenesis

KW - Bacteriophages

KW - Collagen

KW - Growth factors, VEGF

UR - http://www.scopus.com/inward/record.url?scp=84956643889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956643889&partnerID=8YFLogxK

U2 - 10.1002/adhm.201500534

DO - 10.1002/adhm.201500534

M3 - Article

VL - 5

SP - 205

EP - 212

JO - Advanced healthcare materials

JF - Advanced healthcare materials

SN - 2192-2640

IS - 2

ER -