Abstract
Objective. To explore whether insertion (1) and deletion (D) polymorphisms within intron 16 of the angiotensin-converting enzyme (ACE) gene confer susceptibility to systemic lupus erylhematosus (SLE) and lupus nephritis (LN). Methods. We surveyed studies of ACE 1/D polymorphism and SLE using Medline and manual searches. We conducted a metaanalysis of the DD genotype (recessive effect). DD and D1 genotype (dominant effect), and D allele of the ACE overall and in each ethnic population. We performed a meta-analysis of ACE 1/D polymorphism in SLE and LN. Results. Thirteen comparison studies were included in our metaanalysis consisting of 1411 patients with SLE and 1551 controls. We found no association of ACE 1/D polymorphism with SLE in the total sample and by ethnic groups. There was a trend for association of the DD genotype (OR 1.212, 95% CI 0.966-1.520. p = 0.097) and the D allele with SLE in Caucasian patients (OR 1.157, 95% CI 0.991-1.349, p = 0.064); however, this was not statistically significant. The metaanalysis also showed no association of the ACE 1/D polymorphisms with LN. Conclusion. This metaanalysis of 2962 subjects showed there is a lack of association of the ACE 1/D polymorphism with SLE and LN.
| Original language | English |
|---|---|
| Pages (from-to) | 698-702 |
| Number of pages | 5 |
| Journal | Journal of Rheumatology |
| Volume | 33 |
| Issue number | 4 |
| Publication status | Published - 2006 Apr 1 |
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Keywords
- Angiotensin-converting enzyme
- Metaanalysis
- Polymorphisms
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Immunology and Allergy
- Rheumatology
- Immunology
Cite this
Angiotensin-converting enzyme insertion/deletion polymorphism and systemic lupus erythematosus : A metaanalysis. / Lee, Young Ho; Rho, Young Hee; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.
In: Journal of Rheumatology, Vol. 33, No. 4, 01.04.2006, p. 698-702.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiotensin-converting enzyme insertion/deletion polymorphism and systemic lupus erythematosus
T2 - A metaanalysis
AU - Lee, Young Ho
AU - Rho, Young Hee
AU - Choi, Sungjae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Objective. To explore whether insertion (1) and deletion (D) polymorphisms within intron 16 of the angiotensin-converting enzyme (ACE) gene confer susceptibility to systemic lupus erylhematosus (SLE) and lupus nephritis (LN). Methods. We surveyed studies of ACE 1/D polymorphism and SLE using Medline and manual searches. We conducted a metaanalysis of the DD genotype (recessive effect). DD and D1 genotype (dominant effect), and D allele of the ACE overall and in each ethnic population. We performed a meta-analysis of ACE 1/D polymorphism in SLE and LN. Results. Thirteen comparison studies were included in our metaanalysis consisting of 1411 patients with SLE and 1551 controls. We found no association of ACE 1/D polymorphism with SLE in the total sample and by ethnic groups. There was a trend for association of the DD genotype (OR 1.212, 95% CI 0.966-1.520. p = 0.097) and the D allele with SLE in Caucasian patients (OR 1.157, 95% CI 0.991-1.349, p = 0.064); however, this was not statistically significant. The metaanalysis also showed no association of the ACE 1/D polymorphisms with LN. Conclusion. This metaanalysis of 2962 subjects showed there is a lack of association of the ACE 1/D polymorphism with SLE and LN.
AB - Objective. To explore whether insertion (1) and deletion (D) polymorphisms within intron 16 of the angiotensin-converting enzyme (ACE) gene confer susceptibility to systemic lupus erylhematosus (SLE) and lupus nephritis (LN). Methods. We surveyed studies of ACE 1/D polymorphism and SLE using Medline and manual searches. We conducted a metaanalysis of the DD genotype (recessive effect). DD and D1 genotype (dominant effect), and D allele of the ACE overall and in each ethnic population. We performed a meta-analysis of ACE 1/D polymorphism in SLE and LN. Results. Thirteen comparison studies were included in our metaanalysis consisting of 1411 patients with SLE and 1551 controls. We found no association of ACE 1/D polymorphism with SLE in the total sample and by ethnic groups. There was a trend for association of the DD genotype (OR 1.212, 95% CI 0.966-1.520. p = 0.097) and the D allele with SLE in Caucasian patients (OR 1.157, 95% CI 0.991-1.349, p = 0.064); however, this was not statistically significant. The metaanalysis also showed no association of the ACE 1/D polymorphisms with LN. Conclusion. This metaanalysis of 2962 subjects showed there is a lack of association of the ACE 1/D polymorphism with SLE and LN.
KW - Angiotensin-converting enzyme
KW - Metaanalysis
KW - Polymorphisms
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=33645835498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645835498&partnerID=8YFLogxK
M3 - Article
C2 - 16583472
AN - SCOPUS:33645835498
VL - 33
SP - 698
EP - 702
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 4
ER -