Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue

Mi H. Lee, Hye K. Song, Gang Jee Ko, Young Sun Kang, Sang Y. Han, Kum H. Han, Hyoung K. Kim, Jee Y. Han, Dae-Ryong Cha

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Adipose tissue is recognized as a pivotal organ in the development of insulin resistance. This study seeks to determine the effect of angiotensin receptor blockade (ARB) on insulin resistance of adipocytes in culture and in a rat model of type 2 diabetes. Treatment of Otsuka Long-Evans Tokushima Fatty rats with the ARB L158809 for six months significantly lowered fasting plasma glucose, cholesterol and triglyceride levels but led to higher plasma adiponectin levels. Insulin resistance, measured by an intraperitoneal glucose tolerance test, of the treated rats was significantly improved along with an increase in the number of small differentiated adipocytes; however, epididymal fat mass decreased. Treatment significantly lowered lipid peroxidation and MCP-1 expression while increasing adiponectin production by the adipose tissue. ARB treatment significantly improved insulin sensitivity and markedly suppressed AT2-induced oxidative stress, PAI-1 and MCP-1 levels and NF-κB activation of adipocytes in culture. Treatment increased adiponectin and PPARγ expression along with intracellular triglyceride levels reflecting differentiation of the cultured adipocytes. Our study suggests that ARB treatment improves insulin resistance by modification of adipose tissue thereby blunting the development of diabetes.

Original languageEnglish
Pages (from-to)890-900
Number of pages11
JournalKidney International
Volume74
Issue number7
DOIs
Publication statusPublished - 2008 Oct 1

Fingerprint

Angiotensin Receptor Antagonists
Angiotensin Receptors
Insulin Resistance
Adipose Tissue
Adipocytes
Adiponectin
Triglycerides
Inbred OLETF Rats
Peroxisome Proliferator-Activated Receptors
Plasminogen Activator Inhibitor 1
Glucose Tolerance Test
Type 2 Diabetes Mellitus
Lipid Peroxidation
Fasting
Oxidative Stress
Fats
Cholesterol
Glucose

Keywords

  • Adipocytokine
  • Adipose tissue
  • Angiotensin receptor antagonist
  • Diabetes mellitus
  • Insulin resistance
  • Nuclear factor-κB

ASJC Scopus subject areas

  • Nephrology

Cite this

Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue. / Lee, Mi H.; Song, Hye K.; Ko, Gang Jee; Kang, Young Sun; Han, Sang Y.; Han, Kum H.; Kim, Hyoung K.; Han, Jee Y.; Cha, Dae-Ryong.

In: Kidney International, Vol. 74, No. 7, 01.10.2008, p. 890-900.

Research output: Contribution to journalArticle

Lee, Mi H. ; Song, Hye K. ; Ko, Gang Jee ; Kang, Young Sun ; Han, Sang Y. ; Han, Kum H. ; Kim, Hyoung K. ; Han, Jee Y. ; Cha, Dae-Ryong. / Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue. In: Kidney International. 2008 ; Vol. 74, No. 7. pp. 890-900.
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