ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

Gina M. Story, Andrea M. Peier, Alison J. Reeve, Samer R. Eid, Johannes Mosbacher, Todd R. Hricik, Taryn J. Earley, Anne C. Hergarden, David A. Andersson, Sun Wook Hwang, Peter McIntyre, Tim Jegla, Stuart Bevan, Ardem Patapoutian

Research output: Contribution to journalArticle

1650 Citations (Scopus)

Abstract

Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

Original languageEnglish
Pages (from-to)819-829
Number of pages11
JournalCell
Volume112
Issue number6
DOIs
Publication statusPublished - 2003 Mar 21
Externally publishedYes

Fingerprint

Nociceptors
Menthol
Neurons
Mammals
Capsaicin
Sensory Receptor Cells
Temperature
Neurology
Hot Temperature
TRPV Cation Channels
Chemical activation
Peripheral Nervous System
Amino Acids

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., ... Patapoutian, A. (2003). ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell, 112(6), 819-829. https://doi.org/10.1016/S0092-8674(03)00158-2

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. / Story, Gina M.; Peier, Andrea M.; Reeve, Alison J.; Eid, Samer R.; Mosbacher, Johannes; Hricik, Todd R.; Earley, Taryn J.; Hergarden, Anne C.; Andersson, David A.; Hwang, Sun Wook; McIntyre, Peter; Jegla, Tim; Bevan, Stuart; Patapoutian, Ardem.

In: Cell, Vol. 112, No. 6, 21.03.2003, p. 819-829.

Research output: Contribution to journalArticle

Story, GM, Peier, AM, Reeve, AJ, Eid, SR, Mosbacher, J, Hricik, TR, Earley, TJ, Hergarden, AC, Andersson, DA, Hwang, SW, McIntyre, P, Jegla, T, Bevan, S & Patapoutian, A 2003, 'ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures', Cell, vol. 112, no. 6, pp. 819-829. https://doi.org/10.1016/S0092-8674(03)00158-2
Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-829. https://doi.org/10.1016/S0092-8674(03)00158-2
Story, Gina M. ; Peier, Andrea M. ; Reeve, Alison J. ; Eid, Samer R. ; Mosbacher, Johannes ; Hricik, Todd R. ; Earley, Taryn J. ; Hergarden, Anne C. ; Andersson, David A. ; Hwang, Sun Wook ; McIntyre, Peter ; Jegla, Tim ; Bevan, Stuart ; Patapoutian, Ardem. / ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. In: Cell. 2003 ; Vol. 112, No. 6. pp. 819-829.
@article{56ff87e4fcdd4bb6ac4dfff1c3fd5e36,
title = "ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures",
abstract = "Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.",
author = "Story, {Gina M.} and Peier, {Andrea M.} and Reeve, {Alison J.} and Eid, {Samer R.} and Johannes Mosbacher and Hricik, {Todd R.} and Earley, {Taryn J.} and Hergarden, {Anne C.} and Andersson, {David A.} and Hwang, {Sun Wook} and Peter McIntyre and Tim Jegla and Stuart Bevan and Ardem Patapoutian",
year = "2003",
month = "3",
day = "21",
doi = "10.1016/S0092-8674(03)00158-2",
language = "English",
volume = "112",
pages = "819--829",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

AU - Story, Gina M.

AU - Peier, Andrea M.

AU - Reeve, Alison J.

AU - Eid, Samer R.

AU - Mosbacher, Johannes

AU - Hricik, Todd R.

AU - Earley, Taryn J.

AU - Hergarden, Anne C.

AU - Andersson, David A.

AU - Hwang, Sun Wook

AU - McIntyre, Peter

AU - Jegla, Tim

AU - Bevan, Stuart

AU - Patapoutian, Ardem

PY - 2003/3/21

Y1 - 2003/3/21

N2 - Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

AB - Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

UR - http://www.scopus.com/inward/record.url?scp=0345616438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345616438&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(03)00158-2

DO - 10.1016/S0092-8674(03)00158-2

M3 - Article

C2 - 12654248

AN - SCOPUS:0345616438

VL - 112

SP - 819

EP - 829

JO - Cell

JF - Cell

SN - 0092-8674

IS - 6

ER -