Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea

Eun Lee, Chul Hong Kim, Yong Ju Lee, Hyo Bin Kim, Bong Seong Kim, Hyung Young Kim, Yunsun Kim, Sangyoung Kim, Chorong Park, Ju Hee Seo, In Suk Sol, Myongsoon Sung, Min Seob Song, Dae Jin Song, Young Min Ahn, Hea Lin Oh, Jinho Yu, Sungsu Jung, Kyung Suk Lee, Ju Suk LeeGwang Cheon Jang, Yoon Young Jang, Eun Hee Chung, Hai Lee Chung, Sung Min Choi, Yun Jung Choi, Man Yong Han, Jung Yeon Shim, Jin Tack Kim, Chang Keun Kim, Hyeon Jong Yang

Research output: Contribution to journalArticle

Abstract

Background: Community-acquired pneumonia (CAP) is one of the leading worldwide causes of childhood morbidity and mortality. Its disease burden varies by age and etiology and is time dependent. We aimed to investigate the annual and seasonal patterns in etiologies of pediatric CAP requiring hospitalization. Methods: We conducted a retrospective study in 30,994 children (aged 0-18 years) with CAP between 2010 and 2015 at 23 nationwide hospitals in South Korea. Mycoplasma pneumoniae (MP) pneumonia was clinically classified as macrolide-sensitive MP, macrolide-less effective MP (MLEP), and macrolide-refractory MP (MRMP) based on fever duration after initiation of macrolide treatment, regardless of the results of in vitro macrolide sensitivity tests. Results: MP and respiratory syncytial virus (RSV) were the two most commonly identified pathogens of CAP. With the two epidemics of MP pneumonia (2011 and 2015), the rates of clinical MLEP and MRMP pneumonia showed increasing trends of 36.4% of the total MP pneumonia. In children < 2 years of age, RSV (34.0%) was the most common cause of CAP, followed by MP (9.4%); however, MP was the most common cause of CAP in children aged 2-18 years of age (45.3%). Systemic corticosteroid was most commonly administered for MP pneumonia. The rate of hospitalization in intensive care units was the highest for RSV pneumonia, and ventilator care was most commonly needed in cases of adenovirus pneumonia. Conclusions: The present study provides fundamental data to establish public health policies to decrease the disease burden due to CAP and improve pediatric health.

Original languageEnglish
Article number132
JournalBMC infectious diseases
Volume20
Issue number1
DOIs
Publication statusPublished - 2020 Feb 12

Keywords

  • Children
  • Macrolide less-effective
  • Macrolide- refractory
  • Macrolide-sensitive
  • Mycoplasma pneumoniae
  • Pneumonia
  • Respiratory virus

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Lee, E., Kim, C. H., Lee, Y. J., Kim, H. B., Kim, B. S., Kim, H. Y., Kim, Y., Kim, S., Park, C., Seo, J. H., Sol, I. S., Sung, M., Song, M. S., Song, D. J., Ahn, Y. M., Oh, H. L., Yu, J., Jung, S., Lee, K. S., ... Yang, H. J. (2020). Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea. BMC infectious diseases, 20(1), [132]. https://doi.org/10.1186/s12879-020-4810-9