Anoctamin-1 affects the migration and invasion of anaplastic thyroid carcinoma cells

Jae Young Kim, Hwa Young Youn, June Choi, Seung-Kuk Baek, Soon Young Kwon, Bok Kee Eun, Jae-Yong Park, Kyoung Ho Oh

Research output: Contribution to journalArticle

Abstract

Anaplastic thyroid carcinoma (ATC) is a rare malignancy with very poor prognosis. The exact cause underlying its strong aggressive nature is not clear. Here, we discovered the elevated expression of anoctamin-1 (ANO1; Ca 2+ -activated Cl channels) in advanced-stage ATC tissue. Using different ATC cell lines, the degree of expression of ANO1 was found to be related to the degree of ATC cell invasion by quantitative reverse transcription polymerase chain reaction and western blotting. Suppression of ANO1 activity either by selective inhibitor (T16Ainh-A01) or by siRNA significantly attenuated the migration and invasion of ATC cells. In conclusion, ANO1 appears to increase the ability of ATC cells to invade and migrate. Our results also suggest that the expression of ANO1 in patients with ATC may be helpful in predicting the prognosis of ATC.

Original languageEnglish
JournalAnimal Cells and Systems
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Anoctamin
  • invasion
  • migration
  • thyroid cancer

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)

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