Anthropometric measures and serum estrogen metabolism in postmenopausal women: The Women's Health Initiative Observational Study

Hannah Oh, Sally B. Coburn, Charles E. Matthews, Roni T. Falk, Erin S. LeBlanc, Jean Wactawski-Wende, Joshua Sampson, Ruth M. Pfeiffer, Louise A. Brinton, Nicolas Wentzensen, Garnet L. Anderson, Jo Ann E. Manson, Chu Chen, Oleg Zaslavsky, Xia Xu, Britton Trabert

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measured current body mass index (BMI), waist-to-hip ratio (WHR), height, and self-reported BMI at age 18 years were associated with serum estrogens/estrogen metabolites using baseline, cross-sectional data from 1835 postmenopausal women enrolled in the Women's Health Initiative Observational Study. Methods: Fifteen estrogens/estrogen metabolites were quantified using liquid chromatography-tandem mass spectrometry. Geometric means (GMs) of estrogens/estrogen metabolites (in picomoles per liter) were estimated using inverse probability weighted linear regression, adjusting for potential confounders and stratified on menopausal hormone therapy (MHT) use. Results: Among never or former MHT users, current BMI (≥30 vs. <25 kg/m 2 ) was positively associated with parent estrogens (multivariable adjusted GM 432 vs. 239 pmol/L for estrone, 74 vs. 46 pmol/L for estradiol; p-trend < 0.001 for both) and all of the 2-, 4-, and 16-pathway estrogen metabolites evaluated (all p-trend ≤ 0.02). After additional adjustment for estradiol, unconjugated methylated 2-catechols were inversely associated (e.g., 2-methoxyestrone multivariable GM 9.3 vs. 12.0 pmol/L; p-trend < 0.001). Among current MHT users, current BMI was not associated with parent estrogens but was inversely associated with methylated catechols (e.g., 2-methoxyestrone multivariable GM 216 vs. 280 pmol/L; p-trend = 0.008). Similar patterns of association were found with WHR; however, the associations were not independent of BMI. Height and BMI at age 18 years were not associated with postmenopausal estrogens/estrogen metabolite levels. Conclusions: Our data suggest that postmenopausal BMI is associated with increased circulating levels of parent estrogens and reduced methylation of catechol estrogen metabolites, the estrogen metabolism patterns that have previously been associated with higher breast cancer risk.

Original languageEnglish
Article number28
JournalBreast Cancer Research
Volume19
Issue number1
DOIs
Publication statusPublished - 2017 Mar 11
Externally publishedYes

Fingerprint

Women's Health
Observational Studies
Estrogens
Serum
Body Mass Index
Catechols
Hormones
Waist-Hip Ratio
Estradiol
Catechol Estrogens
Estrone
Tandem Mass Spectrometry
Liquid Chromatography
Methylation
Linear Models
Therapeutics

Keywords

  • BMI
  • Estrogen
  • Estrogen metabolites
  • Height
  • Postmenopausal
  • Sex hormones
  • WHR

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Anthropometric measures and serum estrogen metabolism in postmenopausal women : The Women's Health Initiative Observational Study. / Oh, Hannah; Coburn, Sally B.; Matthews, Charles E.; Falk, Roni T.; LeBlanc, Erin S.; Wactawski-Wende, Jean; Sampson, Joshua; Pfeiffer, Ruth M.; Brinton, Louise A.; Wentzensen, Nicolas; Anderson, Garnet L.; Manson, Jo Ann E.; Chen, Chu; Zaslavsky, Oleg; Xu, Xia; Trabert, Britton.

In: Breast Cancer Research, Vol. 19, No. 1, 28, 11.03.2017.

Research output: Contribution to journalArticle

Oh, H, Coburn, SB, Matthews, CE, Falk, RT, LeBlanc, ES, Wactawski-Wende, J, Sampson, J, Pfeiffer, RM, Brinton, LA, Wentzensen, N, Anderson, GL, Manson, JAE, Chen, C, Zaslavsky, O, Xu, X & Trabert, B 2017, 'Anthropometric measures and serum estrogen metabolism in postmenopausal women: The Women's Health Initiative Observational Study', Breast Cancer Research, vol. 19, no. 1, 28. https://doi.org/10.1186/s13058-017-0810-0
Oh, Hannah ; Coburn, Sally B. ; Matthews, Charles E. ; Falk, Roni T. ; LeBlanc, Erin S. ; Wactawski-Wende, Jean ; Sampson, Joshua ; Pfeiffer, Ruth M. ; Brinton, Louise A. ; Wentzensen, Nicolas ; Anderson, Garnet L. ; Manson, Jo Ann E. ; Chen, Chu ; Zaslavsky, Oleg ; Xu, Xia ; Trabert, Britton. / Anthropometric measures and serum estrogen metabolism in postmenopausal women : The Women's Health Initiative Observational Study. In: Breast Cancer Research. 2017 ; Vol. 19, No. 1.
@article{fc745ca04d0f4d569f19ab63b6713f9f,
title = "Anthropometric measures and serum estrogen metabolism in postmenopausal women: The Women's Health Initiative Observational Study",
abstract = "Background: Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measured current body mass index (BMI), waist-to-hip ratio (WHR), height, and self-reported BMI at age 18 years were associated with serum estrogens/estrogen metabolites using baseline, cross-sectional data from 1835 postmenopausal women enrolled in the Women's Health Initiative Observational Study. Methods: Fifteen estrogens/estrogen metabolites were quantified using liquid chromatography-tandem mass spectrometry. Geometric means (GMs) of estrogens/estrogen metabolites (in picomoles per liter) were estimated using inverse probability weighted linear regression, adjusting for potential confounders and stratified on menopausal hormone therapy (MHT) use. Results: Among never or former MHT users, current BMI (≥30 vs. <25 kg/m 2 ) was positively associated with parent estrogens (multivariable adjusted GM 432 vs. 239 pmol/L for estrone, 74 vs. 46 pmol/L for estradiol; p-trend < 0.001 for both) and all of the 2-, 4-, and 16-pathway estrogen metabolites evaluated (all p-trend ≤ 0.02). After additional adjustment for estradiol, unconjugated methylated 2-catechols were inversely associated (e.g., 2-methoxyestrone multivariable GM 9.3 vs. 12.0 pmol/L; p-trend < 0.001). Among current MHT users, current BMI was not associated with parent estrogens but was inversely associated with methylated catechols (e.g., 2-methoxyestrone multivariable GM 216 vs. 280 pmol/L; p-trend = 0.008). Similar patterns of association were found with WHR; however, the associations were not independent of BMI. Height and BMI at age 18 years were not associated with postmenopausal estrogens/estrogen metabolite levels. Conclusions: Our data suggest that postmenopausal BMI is associated with increased circulating levels of parent estrogens and reduced methylation of catechol estrogen metabolites, the estrogen metabolism patterns that have previously been associated with higher breast cancer risk.",
keywords = "BMI, Estrogen, Estrogen metabolites, Height, Postmenopausal, Sex hormones, WHR",
author = "Hannah Oh and Coburn, {Sally B.} and Matthews, {Charles E.} and Falk, {Roni T.} and LeBlanc, {Erin S.} and Jean Wactawski-Wende and Joshua Sampson and Pfeiffer, {Ruth M.} and Brinton, {Louise A.} and Nicolas Wentzensen and Anderson, {Garnet L.} and Manson, {Jo Ann E.} and Chu Chen and Oleg Zaslavsky and Xia Xu and Britton Trabert",
year = "2017",
month = "3",
day = "11",
doi = "10.1186/s13058-017-0810-0",
language = "English",
volume = "19",
journal = "Breast Cancer Research",
issn = "1465-5411",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Anthropometric measures and serum estrogen metabolism in postmenopausal women

T2 - The Women's Health Initiative Observational Study

AU - Oh, Hannah

AU - Coburn, Sally B.

AU - Matthews, Charles E.

AU - Falk, Roni T.

AU - LeBlanc, Erin S.

AU - Wactawski-Wende, Jean

AU - Sampson, Joshua

AU - Pfeiffer, Ruth M.

AU - Brinton, Louise A.

AU - Wentzensen, Nicolas

AU - Anderson, Garnet L.

AU - Manson, Jo Ann E.

AU - Chen, Chu

AU - Zaslavsky, Oleg

AU - Xu, Xia

AU - Trabert, Britton

PY - 2017/3/11

Y1 - 2017/3/11

N2 - Background: Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measured current body mass index (BMI), waist-to-hip ratio (WHR), height, and self-reported BMI at age 18 years were associated with serum estrogens/estrogen metabolites using baseline, cross-sectional data from 1835 postmenopausal women enrolled in the Women's Health Initiative Observational Study. Methods: Fifteen estrogens/estrogen metabolites were quantified using liquid chromatography-tandem mass spectrometry. Geometric means (GMs) of estrogens/estrogen metabolites (in picomoles per liter) were estimated using inverse probability weighted linear regression, adjusting for potential confounders and stratified on menopausal hormone therapy (MHT) use. Results: Among never or former MHT users, current BMI (≥30 vs. <25 kg/m 2 ) was positively associated with parent estrogens (multivariable adjusted GM 432 vs. 239 pmol/L for estrone, 74 vs. 46 pmol/L for estradiol; p-trend < 0.001 for both) and all of the 2-, 4-, and 16-pathway estrogen metabolites evaluated (all p-trend ≤ 0.02). After additional adjustment for estradiol, unconjugated methylated 2-catechols were inversely associated (e.g., 2-methoxyestrone multivariable GM 9.3 vs. 12.0 pmol/L; p-trend < 0.001). Among current MHT users, current BMI was not associated with parent estrogens but was inversely associated with methylated catechols (e.g., 2-methoxyestrone multivariable GM 216 vs. 280 pmol/L; p-trend = 0.008). Similar patterns of association were found with WHR; however, the associations were not independent of BMI. Height and BMI at age 18 years were not associated with postmenopausal estrogens/estrogen metabolite levels. Conclusions: Our data suggest that postmenopausal BMI is associated with increased circulating levels of parent estrogens and reduced methylation of catechol estrogen metabolites, the estrogen metabolism patterns that have previously been associated with higher breast cancer risk.

AB - Background: Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measured current body mass index (BMI), waist-to-hip ratio (WHR), height, and self-reported BMI at age 18 years were associated with serum estrogens/estrogen metabolites using baseline, cross-sectional data from 1835 postmenopausal women enrolled in the Women's Health Initiative Observational Study. Methods: Fifteen estrogens/estrogen metabolites were quantified using liquid chromatography-tandem mass spectrometry. Geometric means (GMs) of estrogens/estrogen metabolites (in picomoles per liter) were estimated using inverse probability weighted linear regression, adjusting for potential confounders and stratified on menopausal hormone therapy (MHT) use. Results: Among never or former MHT users, current BMI (≥30 vs. <25 kg/m 2 ) was positively associated with parent estrogens (multivariable adjusted GM 432 vs. 239 pmol/L for estrone, 74 vs. 46 pmol/L for estradiol; p-trend < 0.001 for both) and all of the 2-, 4-, and 16-pathway estrogen metabolites evaluated (all p-trend ≤ 0.02). After additional adjustment for estradiol, unconjugated methylated 2-catechols were inversely associated (e.g., 2-methoxyestrone multivariable GM 9.3 vs. 12.0 pmol/L; p-trend < 0.001). Among current MHT users, current BMI was not associated with parent estrogens but was inversely associated with methylated catechols (e.g., 2-methoxyestrone multivariable GM 216 vs. 280 pmol/L; p-trend = 0.008). Similar patterns of association were found with WHR; however, the associations were not independent of BMI. Height and BMI at age 18 years were not associated with postmenopausal estrogens/estrogen metabolite levels. Conclusions: Our data suggest that postmenopausal BMI is associated with increased circulating levels of parent estrogens and reduced methylation of catechol estrogen metabolites, the estrogen metabolism patterns that have previously been associated with higher breast cancer risk.

KW - BMI

KW - Estrogen

KW - Estrogen metabolites

KW - Height

KW - Postmenopausal

KW - Sex hormones

KW - WHR

UR - http://www.scopus.com/inward/record.url?scp=85014893043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014893043&partnerID=8YFLogxK

U2 - 10.1186/s13058-017-0810-0

DO - 10.1186/s13058-017-0810-0

M3 - Article

C2 - 28284224

AN - SCOPUS:85014893043

VL - 19

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-5411

IS - 1

M1 - 28

ER -