Anti-adhesive effect of GUARDIX-SL® after intact canal wall mastoidectomy: Preliminary study

Jeong Hoon Lee, Ha Kyun Kim, Young Gi Cinn, Jiwon Chang, Hak Hyun Jung, Gi Jung Im

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Objectives: Adhesion of middle ear and mastoid cavity after mastoidectomy represents a potential source of surgical failure. GUARDIX-SL®, absorbable anti-adhesive material, which is composed of sodium hyaluronate and sodium carboxymethyl cellulose, is an effective agent that widely used as a surgical adjuvant to decrease adhesion in the surgery. Therefore, we evaluated the clinical efficacy of the GUARDIX-SL® for the prevention of adhesion after mastoidectomy. Subjects and Methods: This study was randomized and double-blinded. Conventional intact canal wall mastoidectomy was conducted in both control (n=14) and study group (n=10). To avoid bias because of different surgeons, we only included patients who were operated on by one surgeon. In the study group, 1.5 g GUARDIX-SL® was applied in the mastoid cavity at the end of mastoidectomy. To evaluate anti-adhesive effect of GUARDIX-SL®, the volume of aerated area in the mastoid cavity was calculated and compared with temporal bone computed tomography performed at preoperatively and postoperatively. Besides, to assess the success of operation, pure tone audiometry was also performed at preoperatively and postoperatively. Results: The volume of aerated area of mastoid cavity after mastoidectomy was more increased in GUARDIX-SL® group, but was not statistically significant in the GUARDIX-SL® group than the control. And all results of pure tone audiometry satisfied the criteria of successful operation which has been suggested by Otological Society of Korea. Conclusion: The results suggest that GUARDIX-SL® may be an efficacious and safe material in decreasing the incidence of adhesion after mastoidectomy.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalKorean Journal of Audiology
Volume15
Issue number1
Publication statusPublished - 2011 Apr 1

Fingerprint

Mastoid
Adhesives
Pure-Tone Audiometry
Carboxymethylcellulose Sodium
Temporal Bone
Middle Ear
Hyaluronic Acid
Korea
Sodium
Tomography
Control Groups
Incidence
Surgeons

Keywords

  • Carboxymethylcellulose sodium
  • Hyaluronic acid
  • Mastoid
  • Tissue adhesion
  • Tympanoplasty

ASJC Scopus subject areas

  • Sensory Systems
  • Speech and Hearing

Cite this

Anti-adhesive effect of GUARDIX-SL® after intact canal wall mastoidectomy : Preliminary study. / Lee, Jeong Hoon; Kim, Ha Kyun; Cinn, Young Gi; Chang, Jiwon; Jung, Hak Hyun; Im, Gi Jung.

In: Korean Journal of Audiology, Vol. 15, No. 1, 01.04.2011, p. 14-18.

Research output: Contribution to journalArticle

Lee, Jeong Hoon ; Kim, Ha Kyun ; Cinn, Young Gi ; Chang, Jiwon ; Jung, Hak Hyun ; Im, Gi Jung. / Anti-adhesive effect of GUARDIX-SL® after intact canal wall mastoidectomy : Preliminary study. In: Korean Journal of Audiology. 2011 ; Vol. 15, No. 1. pp. 14-18.
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abstract = "Background and Objectives: Adhesion of middle ear and mastoid cavity after mastoidectomy represents a potential source of surgical failure. GUARDIX-SL{\circledR}, absorbable anti-adhesive material, which is composed of sodium hyaluronate and sodium carboxymethyl cellulose, is an effective agent that widely used as a surgical adjuvant to decrease adhesion in the surgery. Therefore, we evaluated the clinical efficacy of the GUARDIX-SL{\circledR} for the prevention of adhesion after mastoidectomy. Subjects and Methods: This study was randomized and double-blinded. Conventional intact canal wall mastoidectomy was conducted in both control (n=14) and study group (n=10). To avoid bias because of different surgeons, we only included patients who were operated on by one surgeon. In the study group, 1.5 g GUARDIX-SL{\circledR} was applied in the mastoid cavity at the end of mastoidectomy. To evaluate anti-adhesive effect of GUARDIX-SL{\circledR}, the volume of aerated area in the mastoid cavity was calculated and compared with temporal bone computed tomography performed at preoperatively and postoperatively. Besides, to assess the success of operation, pure tone audiometry was also performed at preoperatively and postoperatively. Results: The volume of aerated area of mastoid cavity after mastoidectomy was more increased in GUARDIX-SL{\circledR} group, but was not statistically significant in the GUARDIX-SL{\circledR} group than the control. And all results of pure tone audiometry satisfied the criteria of successful operation which has been suggested by Otological Society of Korea. Conclusion: The results suggest that GUARDIX-SL{\circledR} may be an efficacious and safe material in decreasing the incidence of adhesion after mastoidectomy.",
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