Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris

Shi Yong Ryu, Min Ho Oak, Seok Keun Yoon, Dong Im Cho, Gyurng Soo Yoo, Tae Sung Kim, Kyeong Man Kim

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

The activity-guided fractionation of the extract of the herb of Prunella vulgaris (Labiatae) led to the isolation of four triterpenes, i.e., betulinic acid, ursolic acid, 2α,3α-dihydroxyurs-12-en-28-oic acid, and 2α- hydroxyursolic acid. One of these compounds; 2α,3α-dihydroxyursolic acid, demonstrated significant inhibition on the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner; the IC50 value was calculated to be 57 μM. When the isolated compounds were tested for their effects on the production of nitric oxide from cultured murine macrophages, RAW 264.7 cells, ursolic acid and 2α-hydroxyursolic acid exhibited strong inhibitory activities (IC50 values, 17 and 27 μM, respectively).

Original languageEnglish
Pages (from-to)358-360
Number of pages3
JournalPlanta Medica
Volume66
Issue number4
DOIs
Publication statusPublished - 2000 Jun 22
Externally publishedYes

Fingerprint

Prunella
Prunella vulgaris
Anti-Allergic Agents
Triterpenes
triterpenoids
Inhibitory Concentration 50
herbs
Anti-Inflammatory Agents
Lamiaceae
Hexosaminidases
ursolic acid
Acids
Macrophages
acids
Fractionation
inhibitory concentration 50
Nitric Oxide
beta-N-acetylhexosaminidase
nitric oxide
fractionation

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Ryu, S. Y., Oak, M. H., Yoon, S. K., Cho, D. I., Yoo, G. S., Kim, T. S., & Kim, K. M. (2000). Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. Planta Medica, 66(4), 358-360. https://doi.org/10.1055/s-2000-8531

Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. / Ryu, Shi Yong; Oak, Min Ho; Yoon, Seok Keun; Cho, Dong Im; Yoo, Gyurng Soo; Kim, Tae Sung; Kim, Kyeong Man.

In: Planta Medica, Vol. 66, No. 4, 22.06.2000, p. 358-360.

Research output: Contribution to journalArticle

Ryu, SY, Oak, MH, Yoon, SK, Cho, DI, Yoo, GS, Kim, TS & Kim, KM 2000, 'Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris', Planta Medica, vol. 66, no. 4, pp. 358-360. https://doi.org/10.1055/s-2000-8531
Ryu, Shi Yong ; Oak, Min Ho ; Yoon, Seok Keun ; Cho, Dong Im ; Yoo, Gyurng Soo ; Kim, Tae Sung ; Kim, Kyeong Man. / Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. In: Planta Medica. 2000 ; Vol. 66, No. 4. pp. 358-360.
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