Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris

Shi Yong Ryu, Min Ho Oak, Seok Keun Yoon, Dong Im Cho, Gyurng Soo Yoo, Tae Sung Kim, Kyeong Man Kim

Research output: Contribution to journalArticlepeer-review

168 Citations (Scopus)

Abstract

The activity-guided fractionation of the extract of the herb of Prunella vulgaris (Labiatae) led to the isolation of four triterpenes, i.e., betulinic acid, ursolic acid, 2α,3α-dihydroxyurs-12-en-28-oic acid, and 2α- hydroxyursolic acid. One of these compounds; 2α,3α-dihydroxyursolic acid, demonstrated significant inhibition on the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner; the IC50 value was calculated to be 57 μM. When the isolated compounds were tested for their effects on the production of nitric oxide from cultured murine macrophages, RAW 264.7 cells, ursolic acid and 2α-hydroxyursolic acid exhibited strong inhibitory activities (IC50 values, 17 and 27 μM, respectively).

Original languageEnglish
Pages (from-to)358-360
Number of pages3
JournalPlanta Medica
Volume66
Issue number4
DOIs
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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