Antizyklische zitrullinierte Peptid-Antikörper bei Psoriasis-Arthritis: eine Metaanalyse der Häufigkeit und Assoziation mit klinischen Merkmalen

Translated title of the contribution: Anti-cyclic citrullinated peptide antibody in psoriatic arthritis: a meta-analysis of its frequency and association with clinical features

Ka Young Kim, Young Ho Lee

Research output: Contribution to journalArticle

Abstract

Objective: This study aimed to investigate the frequency of the anti-cyclic citrullinated peptide (anti-CCP) antibody in patients with psoriatic arthritis (PsA) and to assess its associations with clinical features of this disease. Methods: The Medline, EMBASE, and Cochrane databases were searched for studies that examined anti-CCP antibodies in patients with PsA. Meta-analyses of the frequency of the anti-CCP antibody in these patients and its association with polyarthritis, bone erosion, dactylitis, and enthesitis were then performed. Results: Fourteen studies with a combined total of 3291 patients with PsA met the inclusion criteria for this meta-analysis. The pooled overall frequency of anti-CCP antibodies was 9.8% (95% confidence interval [CI] = 7.1–13.3, p < 0.001). Stratification by ethnicity showed that the anti-CCP antibody frequency was lower in Europeans than in non-Europeans (8.5% vs. 14.0%). The meta-analysis showed a significant association of the anti-CCP antibody with polyarthritis (odds ratio [OR] = 4.390, 95% CI = 2.312–8.333, p < 0.001), bone erosion (OR = 2.800, 95% CI = 1.921–4.081, p < 0.001), and dactylitis (OR = 1.958, 95% CI = 1.340–2.861, p < 0.001). However, there was no association between this antibody and enthesitis. Conclusions: Our meta-analysis demonstrated that the overall frequency of the anti-CCP antibody was 9.8% in patients with PsA, and its presence was associated with increased risks of polyarthritis, bone erosion, and dactylitis, but not of enthesitis.

Translated title of the contributionAnti-cyclic citrullinated peptide antibody in psoriatic arthritis: a meta-analysis of its frequency and association with clinical features
Original languageGerman
Pages (from-to)397-403
Number of pages7
JournalZeitschrift fur Rheumatologie
Volume79
Issue number4
DOIs
Publication statusPublished - 2020 May 1

Keywords

  • Anti-cyclic citrullinated peptide antibody
  • Bone erosion
  • Frequency
  • Polyarthritis
  • Psoriatic arthritis

ASJC Scopus subject areas

  • Rheumatology

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