Anti-diabetic effect of magnesium salt extracts from deep-sea water in C57BLKS/J-db/db mice

Min Hee Hwang, Dong Gun Lee, Eun Byeol Go, Miju Cho, Young Sig Park, Namhyun Chung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Recently, the incidence of diabetes has increased steadily worldwide. Type 2 diabetes constitutes about 90% of all cases of diabetes, and it is associated with many complications. Currently, the drugs for therapy of type 2 diabetes are considerably limited owing to disadvantages such as side effects and high rate of secondary failure. To overcome these problems, it is necessary to develop effective therapeutic agents from safe natural products. Deep-sea water (DSW) is abundant in minerals such as potassium (K), calcium (Ca), and magnesium (Mg). Mg supplements are known for their usefulness in the treatment of type 2 diabetes. In this study, we examined the anti-diabetic effect of Mg salt extracts from DSW in a diabetic mouse model. We observed that the groups treated with Mg salt extract showed better response toward fasting blood glucose level and oral glucose tolerance test when compared to the positive control. Overall, the Mg salt extract improved the symptoms of impaired fasting glucose and glucose tolerance, suggesting that it can be used as an effective agent for the treatment of type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalApplied Biological Chemistry
Volume60
Issue number1
DOIs
Publication statusPublished - 2017 Feb 1

Keywords

  • Anti-diabetic
  • Deep-sea water
  • Diabetes mellitus
  • Magnesium salt extract

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry

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