Anti-glycation effect of gold nanoparticles on collagen

Ji Hoon Kim, Chung Oui Hong, Yun Chang Koo, Hee Don Choi, Kwang Won Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including antiinflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3±4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.

Original languageEnglish
Pages (from-to)260-264
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume35
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1

Fingerprint

Gold
Nanoparticles
Collagen
Skin Aging
Advanced Glycosylation End Products
Dermis
Oxidants
Anti-Inflammatory Agents
Proteins

Keywords

  • Aging
  • Collagen
  • Dermis
  • Glycation
  • Gold nanoparticle

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Anti-glycation effect of gold nanoparticles on collagen. / Kim, Ji Hoon; Hong, Chung Oui; Koo, Yun Chang; Choi, Hee Don; Lee, Kwang Won.

In: Biological and Pharmaceutical Bulletin, Vol. 35, No. 2, 01.02.2012, p. 260-264.

Research output: Contribution to journalArticle

Kim, Ji Hoon ; Hong, Chung Oui ; Koo, Yun Chang ; Choi, Hee Don ; Lee, Kwang Won. / Anti-glycation effect of gold nanoparticles on collagen. In: Biological and Pharmaceutical Bulletin. 2012 ; Vol. 35, No. 2. pp. 260-264.
@article{9babfe127b56446aaeb5e63019dc9e85,
title = "Anti-glycation effect of gold nanoparticles on collagen",
abstract = "Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including antiinflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3±4.2{\%}) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.",
keywords = "Aging, Collagen, Dermis, Glycation, Gold nanoparticle",
author = "Kim, {Ji Hoon} and Hong, {Chung Oui} and Koo, {Yun Chang} and Choi, {Hee Don} and Lee, {Kwang Won}",
year = "2012",
month = "2",
day = "1",
doi = "10.1248/bpb.35.260",
language = "English",
volume = "35",
pages = "260--264",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "2",

}

TY - JOUR

T1 - Anti-glycation effect of gold nanoparticles on collagen

AU - Kim, Ji Hoon

AU - Hong, Chung Oui

AU - Koo, Yun Chang

AU - Choi, Hee Don

AU - Lee, Kwang Won

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including antiinflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3±4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.

AB - Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including antiinflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3±4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.

KW - Aging

KW - Collagen

KW - Dermis

KW - Glycation

KW - Gold nanoparticle

UR - http://www.scopus.com/inward/record.url?scp=84863078915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863078915&partnerID=8YFLogxK

U2 - 10.1248/bpb.35.260

DO - 10.1248/bpb.35.260

M3 - Article

C2 - 22293359

AN - SCOPUS:84863078915

VL - 35

SP - 260

EP - 264

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 2

ER -