Anti-glycation effect of gold nanoparticles on collagen

Ji Hoon Kim, Chung Oui Hong, Yun Chang Koo, Hee Don Choi, Kwang Won Lee

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including antiinflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3±4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.

Original languageEnglish
Pages (from-to)260-264
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Issue number2
Publication statusPublished - 2012 Feb


  • Aging
  • Collagen
  • Dermis
  • Glycation
  • Gold nanoparticle

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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