Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate

Soon Hye Park, Jae Hyoung Song, Taejung Kim, Woon Seob Shin, Gab Man Park, Seokjoon Lee, Young Joo Kim, Pilju Choi, Heejin Kim, Hui Seong Kim, Dur Han Kwon, Hwa Jung Choi, Jungyeob Ham

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11 Citations (Scopus)

Abstract

An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2-6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC 50 ) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC 50 of 7.11 μg/mL, and anti-HRV3 activity, with an IC 50 of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.

Original languageEnglish
Pages (from-to)2222-2233
Number of pages12
JournalMarine Drugs
Volume10
Issue number10
DOIs
Publication statusPublished - 2012 Oct 1
Externally publishedYes

Keywords

  • Antiviral activity
  • Human rhinovirus
  • Neorhodomela aculeate
  • Polybromocatechol compounds
  • Red alga

ASJC Scopus subject areas

  • Drug Discovery

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  • Cite this

    Park, S. H., Song, J. H., Kim, T., Shin, W. S., Park, G. M., Lee, S., Kim, Y. J., Choi, P., Kim, H., Kim, H. S., Kwon, D. H., Choi, H. J., & Ham, J. (2012). Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate. Marine Drugs, 10(10), 2222-2233. https://doi.org/10.3390/md10102222