Anti-inflammatory effect of glucose-lysine Maillard reaction products on intestinal inflammation model in vivo

Chung Oui Hong, Chae Hong Rhee, Min Cheol Pyo, Kwang Won Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Inflammatory bowel diseases (IBDs) are chronic disorders that are characterized by intestinal epithelial inflammation and injury. Currently, the most employed therapies are antibiotics and anti-inflammatory drugs; however, the side effects limit long-term effectiveness. We evaluated the impact of glucose-lysine Maillard reaction products (Glc-Lys MRPs) on colitis, induced in rats by an administration of 5% dextran sulfate sodium (DSS) in drinking water. Glc-Lys MRPs ameliorate DSS-induced colitis, as determined by a decrease in disease index activity, colon weight/length ratio, nitric oxide levels in serum, recovery of body weight loss, colon length and serum lysozyme levels. Furthermore, Glc-Lys MRPs increase the glutathione content and the activity of glutathione peroxidase, superoxide dismutase and catalase, and inhibit lipid peroxidation and myeloperoxidase activity in colon tissues. In particular, Glc-Lys MRPs suppress the mRNA level of the inflammatory cytokines and nuclear factor-κB in colon tissues. This study suggests the potential of Glc-Lys MRPs in preventing or treating IBDs.

Original languageEnglish
Pages (from-to)324-332
Number of pages9
JournalInternational Immunopharmacology
Volume52
DOIs
Publication statusPublished - 2017 Nov 1

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Keywords

  • Colitis
  • Cytokines
  • Dextran sulfate sodium
  • Inflammatory bowel diseases
  • Maillard reaction products

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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