Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes.

Sung Woo Lee, Yun Sik Hong, Chung Min Chun, Jun Dong Moon, Su Jin Kim, In Chul Jung, Young-Hoon Yoon, B. A. Lee, Sungwoo Moon, Sung Hyuk Choi, Chul Kyu Moon

Research output: Contribution to journalArticle

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Abstract

Inflammatory responses are strictly regulated by coordination of pro-inflammatory and anti-inflammatory mediators. Interleukin-4 (IL-4) and interleukin-10 (IL-10) have typically the biologic anti-inflammatory effects on monocytes, but uncertain effects on polymorphonuclear leukocytes (PMNs). The PMNs are the first line of cellular response for host defense during acute inflammation. To modify hyper-inflammatory reaction with biologic anti-inflammatory mediators, we have determined the biologic anti-inflammatory activities of IL-4 and IL-10 on human PMNs. Human PMNs were pretreated with IL-4 or IL-10 and then stimulated with formyl methionyl leucyl phenylalanine (fMLP) for times indicated. The level of H2O2, interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) were determined in the each cell free supernatants. fMLP plays the role of a typical pro-inflammatory agent and, at least in determined conditions, down-regulated TNF release. IL-4 acts as an anti-inflammatory mediator but IL-10 did not show its anti-inflammatory activities on fMLP-stimulated human PMNs. IL-4 and IL-10 have different anti-inflammatory mechanisms. Perhaps, IL-10 needs co-factors to act as an anti-inflammatory mediator.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalJournal of Korean Medical Science
Volume17
Issue number1
Publication statusPublished - 2002 Feb 1

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Interleukin-4
Interleukin-10
Neutrophils
Anti-Inflammatory Agents
methionyl-leucyl-phenylalanine
Interleukin-8
Monocytes
Tumor Necrosis Factor-alpha
Inflammation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lee, S. W., Hong, Y. S., Chun, C. M., Moon, J. D., Kim, S. J., Jung, I. C., ... Moon, C. K. (2002). Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes. Journal of Korean Medical Science, 17(1), 7-14.

Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes. / Lee, Sung Woo; Hong, Yun Sik; Chun, Chung Min; Moon, Jun Dong; Kim, Su Jin; Jung, In Chul; Yoon, Young-Hoon; Lee, B. A.; Moon, Sungwoo; Choi, Sung Hyuk; Moon, Chul Kyu.

In: Journal of Korean Medical Science, Vol. 17, No. 1, 01.02.2002, p. 7-14.

Research output: Contribution to journalArticle

Lee, Sung Woo ; Hong, Yun Sik ; Chun, Chung Min ; Moon, Jun Dong ; Kim, Su Jin ; Jung, In Chul ; Yoon, Young-Hoon ; Lee, B. A. ; Moon, Sungwoo ; Choi, Sung Hyuk ; Moon, Chul Kyu. / Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes. In: Journal of Korean Medical Science. 2002 ; Vol. 17, No. 1. pp. 7-14.
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