Anti-Inflammatory Effects of Stearidonic Acid Mediated by Suppression of NF-κB and MAP-Kinase Pathways in Macrophages

Jeehye Sung, Heemang Jeon, In-Hwan Kim, Heon Sang Jeong, Junsoo Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Stearidonic acid (SDA, 18:4n-3) is an omega-3 polyunsaturated fatty acid present in oils derived from plants of the Boraginaceae family. In this study, we determined the anti-inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. SDA significantly downregulated the levels of the inducible nitric oxide synthase (iNOS) protein, thereby suppressing the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. In addition, SDA inhibited the nuclear translocation and promoter activity of nuclear factor κB (NFκB) and the phosphorylation of mitogen-activated protein kinases (MAPK) such as extracellular signal regulated kinase 1/2, c-jun N terminal kinase, and p38 in LPS-stimulated RAW 264.7 cells. Our results showed that SDA exerted anti-inflammatory effects by suppressing iNOS-mediated NO production via inactivation of NFκB and MAPK signaling pathways.

Original languageEnglish
Pages (from-to)781-787
Number of pages7
JournalLipids
Volume52
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

Keywords

  • Anti-inflammatory
  • Echium oil
  • MAPK (mitogen-activated protein kinases) pathway
  • NFκB (nuclear factor κB)
  • Stearidonic acid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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