Anti-Inflammatory Effects of the Fraction from the Leaves of Pyrus pyrifolia on LPS-Stimulated THP-1 Cells

Gilhye Lee, Jung Hee Kim, Hyun Jae Jang, Ji Won Park, Jae Won Lee, Ok Kyoung Kwon, Jae Hong Kim, Kyung Seop Ahn

Research output: Contribution to journalArticlepeer-review

Abstract

Pyrus pyrifolia Nakai (P. pyrifolia) has been traditionally used in East Asia to treat diseases such as phlegm, cough, hangover, and fever. However, there is no investigation that evaluates the biological activities of the leaves of P. pyrifolia. This study aims at describing the anti-inflammatory effects of PP, a bioactive fraction from the leaves of P. pyrifolia, in lipopolysaccharide (LPS)-stimulated THP-1 cells. Initially, PP decreased the protein and RNA expression of TNF-α, MCP-1, IL-8, and IL-6 induced by LPS. Moreover, PP attenuated the phosphorylation of p38, JNK, and ERK. In addition, after stimulation with LPS, the degradation of IB-α was suppressed by PP, and the phosphorylation of IB-α and p65 was suppressed by PP. Additionally, PP increased HO-1, which controls the production of inflammatory molecules, by activating Nrf2. These results indicated that PP could be used as an anti-inflammatory drug to promote wellness.

Original languageEnglish
Article number4946241
JournalEvidence-based Complementary and Alternative Medicine
Volume2021
DOIs
Publication statusPublished - 2021

ASJC Scopus subject areas

  • Complementary and alternative medicine

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