TY - JOUR
T1 - Anti-Inflammatory ent-Kaurane Diterpenoids from Isodon serra
AU - Xing, Honghong
AU - An, Lijun
AU - Song, Ziteng
AU - Li, Shanshan
AU - Wang, Huimei
AU - Wang, Chunyan
AU - Zhang, Jie
AU - Tuerhong, Muhetaer
AU - Abudukeremu, Munira
AU - Li, Dihua
AU - Lee, Dongho
AU - Xu, Jing
AU - Lall, Namrita
AU - Guo, Yuanqiang
N1 - Funding Information:
This research was supported financially by the National Natural Science Foundation of China (Nos. U1703107, U1801288, and 22077067), the Natural Science Foundation of Tianjin, China (No. 19JCYBJC28100), Hundred Young Academic Leaders Program of Nankai University, the Fundamental Research Funds for the Central Universities, Nankai University (No. 63201236), State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. GTZK201902), and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region (Nos. 2015KL030 and 2017D04019).
Funding Information:
This research was supported financially by the National Natural Science Foundation of China (Nos. U1703107, U1801288, and 22077067), the Natural Science Foundation of Tianjin, China (No. 19JCYBJC28100) Hundred Young Academic Leaders Program of Nankai University, the Fundamental Research Funds for the Central Universities, Nankai University (No. 63201236), State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. GTZK201902) and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region (Nos. 2015KL030 and 2017D04019).
Publisher Copyright:
© 2020 American Chemical Society and American Society of Pharmacognosy.
PY - 2020/10/23
Y1 - 2020/10/23
N2 - Ten new ent-kaurane diterpenoids, including two pairs of epimers 1/2 and 4/5 and a 6,7-seco-ent-kauranoid 10, were obtained from the aerial parts of Isodon serra. The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. An anti-inflammatory assay was applied to evaluate their nitric oxide (NO) inhibitory activities by using LPS-stimulated BV-2 cells. Compounds 1 and 9 exhibited notable NO production inhibition with IC50 values of 15.6 and 7.3 μM, respectively. Moreover, the interactions of some bioactive diterpenoids with inducible nitric oxide synthase (iNOS) were explored by employing molecular docking studies.
AB - Ten new ent-kaurane diterpenoids, including two pairs of epimers 1/2 and 4/5 and a 6,7-seco-ent-kauranoid 10, were obtained from the aerial parts of Isodon serra. The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. An anti-inflammatory assay was applied to evaluate their nitric oxide (NO) inhibitory activities by using LPS-stimulated BV-2 cells. Compounds 1 and 9 exhibited notable NO production inhibition with IC50 values of 15.6 and 7.3 μM, respectively. Moreover, the interactions of some bioactive diterpenoids with inducible nitric oxide synthase (iNOS) were explored by employing molecular docking studies.
UR - http://www.scopus.com/inward/record.url?scp=85094221491&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.9b01281
DO - 10.1021/acs.jnatprod.9b01281
M3 - Article
C2 - 32993289
AN - SCOPUS:85094221491
SN - 0163-3864
VL - 83
SP - 2844
EP - 2853
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 10
ER -