Anti-Inflammatory ent-Kaurane Diterpenoids from Isodon serra

Honghong Xing, Lijun An, Ziteng Song, Shanshan Li, Huimei Wang, Chunyan Wang, Jie Zhang, Muhetaer Tuerhong, Munira Abudukeremu, Dihua Li, Dongho Lee, Jing Xu, Namrita Lall, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Ten new ent-kaurane diterpenoids, including two pairs of epimers 1/2 and 4/5 and a 6,7-seco-ent-kauranoid 10, were obtained from the aerial parts of Isodon serra. The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. An anti-inflammatory assay was applied to evaluate their nitric oxide (NO) inhibitory activities by using LPS-stimulated BV-2 cells. Compounds 1 and 9 exhibited notable NO production inhibition with IC50 values of 15.6 and 7.3 μM, respectively. Moreover, the interactions of some bioactive diterpenoids with inducible nitric oxide synthase (iNOS) were explored by employing molecular docking studies.

Original languageEnglish
Pages (from-to)2844-2853
Number of pages10
JournalJournal of Natural Products
Volume83
Issue number10
DOIs
Publication statusPublished - 2020 Oct 23

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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